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Paper Information

Journal:   INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR)   APRIL 2016 , Volume 10 , Number 2; Page(s) 99 To 105.
 
Paper: 

IN VITRO EFFECTS OF PROPRANOLOL ON T HELPER TYPE 1 CYTOKINE PROFILE IN HUMAN LEUKEMIC T CELLS

 
 
Author(s):  HAJIGHASEMI FATEMEH*, MIRSHAFIEY ABBAS
 
* DEPARTMENT OF IMMUNOLOGY, FACULTY OF MEDICINE, SHAHED UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Introduction: Cytokines are a large group of proteins play a key role in inflammation. Down-regulation of pro-inflammatory cytokines has beneficial effect on heart function. Propranolol, as a non selective beta-adrenergic blocker, has been extensively used for treatment of many cardiovascular problems such as arrhythmias and heart malfunction. In addition anti-inflammatory effects of propranolol have been revealed. In this study the propranolol effect on T helper type 1 cytokine profile in human leukemic T cells has been assessed in vitro. Materials and methods: Human leukemic T cells (Molt-4 and Jurkat) were cultured in complete RPMI medium. The cells were then incubated with different concentrations of propranolol (0.03- 30 mM) in the presence or absence of PHA (10 mg/ml) for 48 hours. The supernatants of cell culture media were collected and used for cytokines assay. Results: Propranolol significantly decreased the T helper type 1 cytokine profile [Interleukin-2 (IL-2) and Interferon- ? (IFN-?)] production in PHA stimulated Molt-4 and Jurkat cells, after 48 hour of incubation time, dose-dependently compared to untreated control cells. Conclusion: Our data showed a dose dependent inhibitory effect of propranolol on the IL-2 and IFN-? production in human leukemic Molt-4 and Jurkat cells. The anti- inflammatory effect of propranolol reported by other investigators may be in part due to its suppressive effect on production of inflammatory cytokines such as IL-2 and IFN-?. So, propranolol along with its chronic long-term usage in cardiovascular problems may have potential implication in treatment of inflammatory-based disorders.

 
Keyword(s): PROPRANOLOL, CYTOKINES, LEUKEMIC, T-CELLS
 
 
References: 
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APA: Copy

HAJIGHASEMI, F., & MIRSHAFIEY, A. (2016). IN VITRO EFFECTS OF PROPRANOLOL ON T HELPER TYPE 1 CYTOKINE PROFILE IN HUMAN LEUKEMIC T CELLS. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), 10(2), 99-105. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511542



Vancouver: Copy

HAJIGHASEMI FATEMEH, MIRSHAFIEY ABBAS. IN VITRO EFFECTS OF PROPRANOLOL ON T HELPER TYPE 1 CYTOKINE PROFILE IN HUMAN LEUKEMIC T CELLS. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR). 2016 [cited 2021July26];10(2):99-105. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511542



IEEE: Copy

HAJIGHASEMI, F., MIRSHAFIEY, A., 2016. IN VITRO EFFECTS OF PROPRANOLOL ON T HELPER TYPE 1 CYTOKINE PROFILE IN HUMAN LEUKEMIC T CELLS. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), [online] 10(2), pp.99-105. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511542.



 
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