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Paper Information

Journal:   INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR)   APRIL 2016 , Volume 10 , Number 2; Page(s) 92 To 98.
 
Paper: 

CLINICAL MANIFESTATIONS OF β-THALASSEMIA MAJOR IN TWO DIFFERENT ALTITUDES, BUSHEHR AND SHAHREKORD

 
 
Author(s):  RAVANBOD MOHAMMAD REZA, MOVAHED ALI, OSTOVAR AFSHIN, HAJIGHOLAMI ALI, KHAMISIPOUR GHOLAMREZA, FARROKHI SHOKROLLAH, DARABI HOSSEIN, KHOSRAVI YASAMAN, GHEYBI MOHAMMAD KAZZEM*
 
* PERSIAN GULF TROPICAL MEDICINE RESEARCH CENTER, BUSHEHR UNIVERSITY OF MEDICAL SCIENCES, BUSHEHR, IRAN
 
Abstract: 

Background: Patients with b-thalassemia major (TM) develop iron overload through increased iron absorption and transfusional therapy and it’s the most important complication of TM. Thalassemia is common in coastal regions and lands with low altitudes. The aim of this study is to determine the effect of high and low altitude on serum ferritin and treatment requirement in two groups of b-thalassemia major (TM) patients. Subjects and Methods: Patients were divided into two groups, the first group (No: 50) living at sea level (in the port of Bushehr, Iran) and the second group (No: 40) living at the altitude of 2061 m (in the city of Shahrekord, Iran). All patient’s clinical history, blood transfusion and laboratory tests including complete blood count and hemoglobin electrophoresis were reviewed. Results: There were no significant difference in ferritin levels, transfusion period and diabetes incidence of the two cities patients (P>0.05). Patient’s cardiac function and liver condition were significantly better in patients of Bushehr (P<0.05). Patients under 20 years in Bushehr were less splenectomized in comparison with Shahrekord (P<0.05). Conclusion: Our result showed that some of clinical manifestations of patients in low altitude such as cardiac and liver condition were better. But it did not affect ferritin level probably due to transfusion and chelating therapy. Totally patients of Bushehr had better conditions and had longer survivals.

 
Keyword(s): β-THALASSEMIA MAJOR, FERRITIN LEVEL, CARDIAC FUNCTION, ALTITUDE
 
 
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APA: Copy

RAVANBOD, M., & MOVAHED, A., & OSTOVAR, A., & HAJIGHOLAMI, A., & KHAMISIPOUR, G., & FARROKHI, S., & DARABI, H., & KHOSRAVI, Y., & GHEYBI, M. (2016). CLINICAL MANIFESTATIONS OF β-THALASSEMIA MAJOR IN TWO DIFFERENT ALTITUDES, BUSHEHR AND SHAHREKORD. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), 10(2), 92-98. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511523



Vancouver: Copy

RAVANBOD MOHAMMAD REZA, MOVAHED ALI, OSTOVAR AFSHIN, HAJIGHOLAMI ALI, KHAMISIPOUR GHOLAMREZA, FARROKHI SHOKROLLAH, DARABI HOSSEIN, KHOSRAVI YASAMAN, GHEYBI MOHAMMAD KAZZEM. CLINICAL MANIFESTATIONS OF β-THALASSEMIA MAJOR IN TWO DIFFERENT ALTITUDES, BUSHEHR AND SHAHREKORD. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR). 2016 [cited 2021July28];10(2):92-98. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511523



IEEE: Copy

RAVANBOD, M., MOVAHED, A., OSTOVAR, A., HAJIGHOLAMI, A., KHAMISIPOUR, G., FARROKHI, S., DARABI, H., KHOSRAVI, Y., GHEYBI, M., 2016. CLINICAL MANIFESTATIONS OF β-THALASSEMIA MAJOR IN TWO DIFFERENT ALTITUDES, BUSHEHR AND SHAHREKORD. INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR), [online] 10(2), pp.92-98. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511523.



 
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