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Paper Information

Journal:   JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES   SPRING 2016 , Volume 6 , Number 1; Page(s) 120 To 128.
 
Paper: 

PREVALENCE OF BLA-CTX-M, BLA-SHV, AND BLA-TEM GENES AND COMPARISON OF ANTIBIOTIC RESISTANCE PATTERN IN EXTENDED-SPECTRUM β-LACTAMASE PRODUCING AND NON-PRODUCING GROUPS OF KLEBSIELLA PNEUMONIAE ISOLATED FROM CLINICAL SAMPLES IN KERMAN HOSPITALS

 
 
Author(s):  MORADI M., NOROUZI A., TAATI MOGHADAM M.*
 
* DEPARTMENT OF MICROBIOLOGY, KERMAN UNIVERSITY OF MEDICAL SCIENCES, KERMAN, IRAN
 
Abstract: 

Background & Objectives: Antibiotic resistance among pathogens bacteria are an important problem noted worldwide. Beta-lactamases that are produced by Enterobacteriaceae have been located mainly on plasmid. Treatment of these bacterial infections which produced b-lactamase are a major problem.
Materials & Methods: 111 Klebsiella pneumoniae isolates were collected from hospitals in Kerman, therefore, antibiotic susceptibility test was performed by disk diffusion method. At first, detection of ESBLs were performed by phenotypic confirmatory test, and presence of bla-SHV, bla-TEM, and bla-CTX-M were detected by PCR.
Results: Resistant to ampicillin (92.5%) was more than others antibiotics, and the imipenem (89%) was the most effective antibiotic against Klebsiella pneumoniae isolates. Additionally, the resistance to all antibiotics in ESBLs-producing Klebsiella pneumoniae was more than that of Non-ESBL Klebsiella pneumoniae. After the detection of bla-SHV, bla-TEM, and bla-CTX-M genes in Klebsiella pneumoniae by PCR, 56 (50.4%) isolates presented these genes.
Conclusion: With regard to high prevalence of ESBLs genes and high level of antibiotic resistance in bacteria, detecting these genes can prevent the extension of antibiotic resistance through these bacteria.

 
Keyword(s): KLEBSIELLA PNEUMONIA, ANTIBIOTIC RESISTANCE, β- LACTAMASE GENES, PCR
 
 
References: 
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Citations: 
 
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APA: Copy

MORADI, M., & NOROUZI, A., & TAATI MOGHADAM, M. (2016). PREVALENCE OF BLA-CTX-M, BLA-SHV, AND BLA-TEM GENES AND COMPARISON OF ANTIBIOTIC RESISTANCE PATTERN IN EXTENDED-SPECTRUM β-LACTAMASE PRODUCING AND NON-PRODUCING GROUPS OF KLEBSIELLA PNEUMONIAE ISOLATED FROM CLINICAL SAMPLES IN KERMAN HOSPITALS. JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES, 6(1), 120-128. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511502



Vancouver: Copy

MORADI M., NOROUZI A., TAATI MOGHADAM M.. PREVALENCE OF BLA-CTX-M, BLA-SHV, AND BLA-TEM GENES AND COMPARISON OF ANTIBIOTIC RESISTANCE PATTERN IN EXTENDED-SPECTRUM β-LACTAMASE PRODUCING AND NON-PRODUCING GROUPS OF KLEBSIELLA PNEUMONIAE ISOLATED FROM CLINICAL SAMPLES IN KERMAN HOSPITALS. JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES. 2016 [cited 2021July25];6(1):120-128. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511502



IEEE: Copy

MORADI, M., NOROUZI, A., TAATI MOGHADAM, M., 2016. PREVALENCE OF BLA-CTX-M, BLA-SHV, AND BLA-TEM GENES AND COMPARISON OF ANTIBIOTIC RESISTANCE PATTERN IN EXTENDED-SPECTRUM β-LACTAMASE PRODUCING AND NON-PRODUCING GROUPS OF KLEBSIELLA PNEUMONIAE ISOLATED FROM CLINICAL SAMPLES IN KERMAN HOSPITALS. JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES, [online] 6(1), pp.120-128. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511502.



 
 
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