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Paper Information

Journal:   JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES   SPRING 2016 , Volume 6 , Number 1; Page(s) 52 To 59.
 
Paper: 

KLEBSIELLA PNEUMONIAE INFECTIONS IN HOSPITALIZED PATIENTS: CHARACTERIZATION OF ANTIBIOTIC CROSS-RESISTANCE AND DETECTION OF CEFEPIME SUSCEPTIBLE-DOSE DEPENDENT (SDD) STRAINS

 
 
Author(s):  POURALI SHESHBLOUKI GHOLAMREZA, MARDANEH J.*, HOSSEINZADEH Z.
 
* DEPARTMENT OF MICROBIOLOGY, SCHOOL OF MEDICINE, GONABAD UNIVERSITY OF MEDICAL SCIENCES, GONABAD, IRAN
 
Abstract: 

Background & Objective: Klebsiella pneumonia (K. pneumoniae) is a Gram-negative enteric bacterium that causes nosocomial infections. The aims of the present study were to identify Klebsiella pneumoniae infections in hospitalized patients: characterization of cross-resistance and antibiotic resistance patterns in isolates and detection of cefepime susceptible-dose dependent in strains.
Materials & Methods: In the present study (during 2014-2015), samples were collected from patients hospitalized in Ghotbadden, Faghihi and Nemazee hospitals (Shiraz, Iran). The isolates were identified as K. pneumoniae, based on the biochemical tests embedded in the API-20E system. The susceptibility testing (disc diffusion) was performed according to the clinical and laboratory standards institute guidelines (CLSI 2014). The dDetection of cefepime susceptible-dose dependent (SDD) was performed. The detection of AmpC
b-lactamases producing strains was done based on the cefoxitin and cefepime disk tests.
Results: In this study 111 strains of Klebsiella pneumoniae were isolated. The less effective drug was ceftazidime (37.8% were sensitive). All SDD strains were susceptible to colistin and imipenem. Colistin (96.4%) and imipenem (88.3%) were the most effective antibiotics against isolates. Respectively, 41.4% and 35.1% isolates displayed resistance to gentamicin and amikacin. All colistin resistant isolates were imipenem sensitive.
Conclusion: Carbapenem drugs are effective against Klebsieella pneumoniae infections. These results indicate that multidrug-resistant strains of K. pneumoniae are rising. The routine investigation and reporting of antibiotics resistance profile in patients presenting with Klebsiella infections is suggested.

 
Keyword(s): HOSPITALIZED PATIENTS, BACTERIAL INFECTION, KLEBSIELLA PNEUMONIAE, ANTIBIOTIC RESISTANCE PATTERN, SUSCEPTIBLE-DOSE DEPENDENT
 
References: 
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