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Paper Information

Journal:   JOURNAL OF FASA UNIVERSITY OF MEDICAL SCIENCES   SPRING 2016 , Volume 6 , Number 1; Page(s) 27 To 34.
 
Paper: 

ASSOCIATION OF RS16953002 FTO GENE POLYMORPHISM WITH TYPE 2 DIABETES AND OBESITY

 
 
Author(s):  BAKHSHI GANJE M., SHEIKHHA M.H.*, FARASHAHI E., MOHAMMADZADE M.
 
* YAZD CLINICAL AND RESEARCH CENTER FOR INFERTILITY, SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCE, BOALI AVENUE, SAFAYEH, YAZD, IRAN
 
Abstract: 

Background & Objective: Genome-wide association studies (GWAS) has identified that FTO gene polymorphisms was associated with the risk of type 2 diabetes and obesity. However, the findings in subsequent studies were inconsistent in various populations. This study aimed to investigate the association of FTO rs16953002 with type 2 diabetes and obesity in Yazd, Iran.
Methods & Materials: Unrelated study subject controls (n=200) and type 2 diabetes cases (T2DM) (n=200), were randomly selected from Yazd, Iran. Genotyping was done by the polymerase chain reaction-restriction fragment length polymorphism method. Age and gender, smoking, weight and body mass index (BMI) were analyzed using the analysis of
c2 test.
Results: The rs16953002 A/G polymorphism of the FTO gene showed significant association with T2DM and obesity. The AG, GG genotypes were significantly higher in T2DM and obese subjects compared to the group subjects.
Conclusions: The result of the present study indicate that the genetic variant in FTO may contribute to T2DM and obesity risk in Yazd population.

 
Keyword(s): FTO GENE, TYPE 2 DIABETES, OBESITY, POLYMORPHISM
 
References: 
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