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Paper Information

Journal:   THE JOURNAL OF NEPHRO-UROLOGY MONTHLY   2016 , Volume 8 , Number 2; Page(s) 0 To 0.
 
Paper: 

ANALYSIS OF THE IL-10, IL-12, AND TNF-α GENE POLYMORPHISMS IN PATIENTS WITH VESICOURETERAL REFLUX AMONG THE SOUTHEAST IRANIAN POPULATION

 
 
Author(s):  KORDI TAMANDANI DOR MOHAMMAD*, NAEIMI NASIM, GHASEMI ALI, BARANZAHI TAYBE, SADEGHI BOJD SIMIN
 
* DEPARTMENT OF BIOLOGY, UNIVERSITY OF SISTAN AND BALUCHESTAN, ZAHEDAN, I.R. IRAN
 
Abstract: 

Background: Vesicoureteral reflux (VUR) is a common childhood disorder that is characterized by the abnormal movement of urine from the bladder into the ureters or kidneys.
Objectives: The aim of this study was to determine whether the genetic polymorphisms of the IL-10, IL-12, and TNF-
a genes are involved in the development of VUR.
Patients and Methods: The tetra amplification mutation refractory system-polymerase chain reaction (Tetra-ARMS PCR) was applied to analyze the four polymorphic sites of the IL-10AG-1082, IL-10CA597, IL-12CA1188, and TNF308GA genes in 124 VUR children and 110 healthy controls.
Results: A significant, highly increased risk of VUR disease was found for the CA, AA, and combined genotypes of IL-10CA597 (OR=5.2, 95% CL: 1.80 - 18.25; P=0.0006, OR=9.1, 95% CL: 1.11 - 122.75; P=0.02, OR=5.3, 95% CL: 1.82 - 18.61; P=0.00052, respectively); the AG, GG, and AG+GG genotypes of IL-10AG-1082 (OR=12.8, 95% CL; 2.9 - 113.9; P=0.00003, OR=12.62, 95% CL: 2.93 - 114.53; P=0.00003, respectively); and the AA genotype of IL-12 (AA, OR=0.19, 95% CL: 0.5 -0.55; P=0.0006). The frequency of the C allele in both IL-10CA and IL-12CA was greater in patients with VUR than in the healthy controls. No association was found between TNF308GA and the risk of VUR.
Conclusions: The results demonstrated significant associations between the IL-10 (AG-1089, IL-10CA) and IL-12 (AA) gene polymorphisms and a highly increased risk of VUR.

 
Keyword(s): VUR, POLYMORPHISM, IL-10, IL-12, TNF- α
 
References: 
 
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