Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   MARCH 2016 , Volume 19 , Number 3; Page(s) 197 To 203.
 
Paper: 

MODULATION OF GUT MICROBIOTA BY BERBERINE IMPROVES STEATOHEPATITIS IN HIGH-FAT DIET-FED BALB/C MICE

 
DOI: 

0161903/AIM.008

 
Author(s):  CAO YI, PAN QIN, CAI WEI, SHEN FENG, CHEN GUANG YU, XU LEI MING*, FAN JIANGAO*
 
* DEPARTMENT OF GASTROENTEROLOGY, XINHUA HOSPITAL, SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE, SHANGHAI KEY LAB OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, SHANGHAI 200092, CHINA
 
Abstract: 

BACKGROUND: Dysbiosis of the gut microbiota underlies non-alcoholic steatohepatitis (NASH). Ingredient of Chinese herbal medicine, berberine, has been proved to regulate the gut microbiota without systemic side effects. Therefore, we explored its effects on NASH induced by high-fat diet (HFD).
METHODS: BALB/c mice were randomized into three groups, including: control, model, and berberine treatment. With the exception of the control group with the standard diet, the model, and the treatment groups were treated by HFD. Mice from treatment group were further subjected to berberine (200 mg/kg/d) gavage since the 5th week. At the end of the 13th week, gut bacteria, liver endotoxin receptor, and inflammation cytokines were assessed by real-time PCR. NASH and its predisposing factors were evaluated biochemically and pathologically.
RESULTS: Compared to their decreases in the model group, berberine administration restored the relative level of Bifidobacteria (2.16 ± 0.63 vs. 0.50 ± 0.08, P < 0.01) and the ratio of Bacteroidetes/ Firmicutes (0.76 ± 0.26 vs. 0.39 ± 0.11, P < 0.01), respectively, in the treatment groups. Microbiota restoration led to significant reductions in body weight, serum levels of lipids, glucose, insulin, and homeostasis model assessment of insulin resistance. Improvements were also observed in the serum transaminase activity and nonalcoholic fatty liver disease activity score, which demonstrated the attenuation of NASH. Mechanically, expression levels of CD14, IL-1, IL-6 and TNF-
a were statistically down-regulated (treatment group vs model group, P < 0.01).
CONCLUSIONS: Berberine alleviates NASH and its predisposing factors. Normalization of gut microbiota might underlie its effect.

 
Keyword(s): BERBERINE, GUT, INFLAMMATION, MICROBIOTA, NONALCOHOLIC STEATOHEPATITIS
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

CAO, Y., & PAN, Q., & CAI, W., & SHEN, F., & CHEN, G., & XU, L., & FAN, J. (2016). MODULATION OF GUT MICROBIOTA BY BERBERINE IMPROVES STEATOHEPATITIS IN HIGH-FAT DIET-FED BALB/C MICE. ARCHIVES OF IRANIAN MEDICINE, 19(3), 197-203. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511262



Vancouver: Copy

CAO YI, PAN QIN, CAI WEI, SHEN FENG, CHEN GUANG YU, XU LEI MING, FAN JIANGAO. MODULATION OF GUT MICROBIOTA BY BERBERINE IMPROVES STEATOHEPATITIS IN HIGH-FAT DIET-FED BALB/C MICE. ARCHIVES OF IRANIAN MEDICINE. 2016 [cited 2021July25];19(3):197-203. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511262



IEEE: Copy

CAO, Y., PAN, Q., CAI, W., SHEN, F., CHEN, G., XU, L., FAN, J., 2016. MODULATION OF GUT MICROBIOTA BY BERBERINE IMPROVES STEATOHEPATITIS IN HIGH-FAT DIET-FED BALB/C MICE. ARCHIVES OF IRANIAN MEDICINE, [online] 19(3), pp.197-203. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511262.



 
  pdf-File
Yearly Visit 58
 
 
Latest on Blog
Enter SID Blog