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Paper Information

Journal:   INTERNATIONAL JOURNAL OF PEDIATRICS   SEPTEMBER 2014 , Volume 2 , Number 3-3 (SUPP 5); Page(s) 5 To 10.
 
Paper: 

THE RELATIONSHIP BETWEEN SEVERE HYPERBILIRUBINEMIA AND ABNORMAL AUDITORY BRAINSTEM RESPONSE (ABR) IN CHILDREN

 
 
Author(s):  PEYVANDI ALI ASGHAR, EFTEKHARIAN ALI, GOLJANIAN TABRIZI ALI*, ALANI NADEREH
 
* FACULTY OF MEDICINE, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Introduction: Hyperbilirubinemia is one of the most common cause of congenital sensory neuronal hearing loss. These patients are screened by auditory brainstem response (ABR) test at bilirubin levels higher than 1% of gestational weight. Aim of this study is to determine whether hyperbilirubinemia less than 1% of gestational weight could induce hearing loss and abnormal auditory brainstem response (ABR).
Materials and Methods: In this case control study the outcome of ABR test in children younger than 3 years old with a history of term delivery and hyperbilirubinemia (bilirubin level less than 1% of gestational weight) were compared with the control group without hyperbilirubinemia matched for age and gender.
Results: Mean ABR amplitude (wave I, V) were significantly prolonged in neonates with jaundice compared with controls (P<0.01). Based on receiver-operating characteristic curves, a bilirubin level of 0.6% of gestational weight was the best discriminator with a sensitivity and specificity of 100%. In logistic regression analysis the relative risk of having an abnormal ABR in bilirubin level>0.6% gestational weight was 2.25 with 95% confidence intervals (CI) (1.44-3.89 and p=0.02).
Conclusion: Our study showed a relevant association between bilirubin levels less than 20 mg/dl and abnormal ABR.

 
Keyword(s): AUDITORY BRAINSTEM RESPONSE, HEARING LOSS, HYPERBILIRUBINEMIA
 
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