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Paper Information

Journal:   ACTA MEDICA IRANICA   2016 , Volume 54 , Number 4; Page(s) 233 To 239.
 
Paper: 

SYNERGISTIC EFFECT OF HONEY AND PROPOLIS ON CUTANEOUS WOUND HEALING IN RATS

 
 
Author(s):  TAKZAREE NASRIN, HADJIAKHONDI ABBAS, HASSANZADEH GHOLAMREZA*, ROUINI MOHAMMAD REZA, MANAYI AZADEH
 
* DEPARTMENT OF ANATOMY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Accelerating wound healing is now considered as a principle clinical treatment and increasing the quality and speed of healing which has always been emphasized by the scientists. Propolis and honey are natural bee products with wide range of biological and medicinal properties. This study was aimed to determine the synergistic effect of honey and propolis in wound healing of rat skin. A total of 75 Wistar rats weighing 200-250 gr were placed under general anesthesia and sterile conditions. Then a square shape wound with 1.5*1.5 mm dimension was made on the back of the neck. Animals were randomly divided into control, honey, propolis, combined honey propolis and phenytoin 1% groups, respectively. Rats were randomly divided into the following groups: 4th, 7th and, 14th days of treatment in each period of study. Wound area in the experimental group was covered once daily with a fixed amount of thyme honey, propolis, propolis and honey and phenytoin cream (1%), the control group did not receive any treatment. For histological studies, during the fourth, seventh and fourteenth day’s rats were sacrificed and samples were taken from the wound and adjacent skin. After histological staining fibroblast, neutrophils, macrophages and vascular sections were counted in the wound bed. The macroscopic and microscopic evaluations showed that the percentage of wound healing on different days in the experimental and control groups were significant (P<0.05). The macroscopic and microscopic evaluation showed that the percentage of wound healing on different days in combined propolis and honey experimental group was significantly different from the control group (Multivariate ANOVA test) (P<0.05). Combined application of propolis and honey on the open wound healing in rats has a synergistic effect.

 
Keyword(s): OPEN CUTANEOUS WOUND, HEALING, HONEY, PROPOLIS, SYNERGISM, RATS
 
 
References: 
 
Citations: 
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APA: Copy

TAKZAREE, N., & HADJIAKHONDI, A., & HASSANZADEH, G., & ROUINI, M., & MANAYI, A. (2016). SYNERGISTIC EFFECT OF HONEY AND PROPOLIS ON CUTANEOUS WOUND HEALING IN RATS. ACTA MEDICA IRANICA, 54(4), 233-239. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511192



Vancouver: Copy

TAKZAREE NASRIN, HADJIAKHONDI ABBAS, HASSANZADEH GHOLAMREZA, ROUINI MOHAMMAD REZA, MANAYI AZADEH. SYNERGISTIC EFFECT OF HONEY AND PROPOLIS ON CUTANEOUS WOUND HEALING IN RATS. ACTA MEDICA IRANICA. 2016 [cited 2021July29];54(4):233-239. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511192



IEEE: Copy

TAKZAREE, N., HADJIAKHONDI, A., HASSANZADEH, G., ROUINI, M., MANAYI, A., 2016. SYNERGISTIC EFFECT OF HONEY AND PROPOLIS ON CUTANEOUS WOUND HEALING IN RATS. ACTA MEDICA IRANICA, [online] 54(4), pp.233-239. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511192.



 
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