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Paper Information

Journal:   ARCHIVES OF CLINICAL INFECTIOUS DISEASES   JULY 2016 , Volume 11 , Number 3; Page(s) 0 To 0.
 
Paper: 

HEPATITIS B CORE ANTIBODY IMMUNOGLOBULIN MIN BLOOD DONORS WITH A HISTORY OF HEPATITIS B VIRUS INFECTION

 
 
Author(s):  AZIMI HELIA, VAEZJALALI MARYAM*
 
* DEPARTMENT OF MICROBIOLOGY, SCHOOL OF MEDICINE, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, I.R. IRAN
 
Abstract: 

Background: Hepatitis B is still an issue after blood transfusion. A reason could be the window period of hepatitis B infection in blood donors. In countries such as Iran hepatitis B surface antigen enzyme-linked immunosorbent assay (ELISA) is the only test to detect the virus in blood donors. This procedure may miss the window period of hepatitis B infected donors.
Objectives: The current study aimed to look for hepatitis B core antibody immunoglobulin M in blood samples of Iranian donors with a history of hepatitis B virus infection to detect window period infection.
Materials and Methods: Eighty serum samples with hepatitis B core antibody were collected from 1000 healthy blood donors, forty of them had been positive for hepatitis B virus DNA in authors’ previous study and were diagnosed as occult hepatitis B infection.
All 80 samples were tested for hepatitis B core immunoglobulin M.
Results: Onethousand blood samples were collectedfrom64 (6.4%) femaleand936 (93.6%) malesubjects. Noneof the blood samples contained hepatitis Bcore immunoglobulin M. The study foundnosignificant differences between male andfemale subjects in term of HBcAb positivity.
Conclusions: Hepatitis B core antibody immunoglobulin M positivity is different in healthy blood donors of different countries according to the prevalence of chronic hepatitis B and its vaccination. Based on the current study findings, all positive samples of hepatitis B core antibody in Iranian blood banks should be considered as candidates for occult hepatitis B not just the window period infected samples.

 
Keyword(s): HEPATITIS B VIRUS, BLOOD DONORS, VIRAL DNA, IMMUNOGLOBULIN M
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

AZIMI, H., & VAEZJALALI, M. (2016). HEPATITIS B CORE ANTIBODY IMMUNOGLOBULIN MIN BLOOD DONORS WITH A HISTORY OF HEPATITIS B VIRUS INFECTION. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, 11(3), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511190



Vancouver: Copy

AZIMI HELIA, VAEZJALALI MARYAM. HEPATITIS B CORE ANTIBODY IMMUNOGLOBULIN MIN BLOOD DONORS WITH A HISTORY OF HEPATITIS B VIRUS INFECTION. ARCHIVES OF CLINICAL INFECTIOUS DISEASES. 2016 [cited 2021July26];11(3):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511190



IEEE: Copy

AZIMI, H., VAEZJALALI, M., 2016. HEPATITIS B CORE ANTIBODY IMMUNOGLOBULIN MIN BLOOD DONORS WITH A HISTORY OF HEPATITIS B VIRUS INFECTION. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, [online] 11(3), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511190.



 
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