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Paper Information

Journal:   ACTA MEDICA IRANICA   2016 , Volume 54 , Number 4; Page(s) 226 To 232.
 
Paper: 

PROTECTIVE EFFECTS OF LITHIUM ON SUMATRIPTAN-INDUCED MEMORY IMPAIRMENT IN MICE

 
 
Author(s):  NIKOUI VAHID, JAVADI PAYDAR MEHRAK, SALEHI MAHTAB, BEHESTANI SELDA, DEHPOUR AHMAD REZA*
 
* DEPARTMENT OF PHARMACOLOGY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Lithium is a drug used for the treatment of bipolar disorder. It has several mechanisms of action, and recently it is shown that lithium can antagonize the 5-HT1B/1D serotonin receptors. Sumatriptan is a 5-HT1B/1D receptor agonist used for the treatment of cluster headaches and migraine which might cause memory impairment as a potential side effect. In this study, effects of lithium on sumatriptan-induced memory impairment have been determined in a two-trial recognition Y-maze and passive avoidance tests.
Male mice weighing 25-30 g were divided into several groups randomly. In Y-maze test, effects of lithium (1, 5, 10, 20, 40, 80 mg/kg) and sumatriptan (1, 5, 10 mg/kg) were assessed on memory acquisition, then lithium (0.1, 1, 10 mg/kg) and sumatriptan (1, 10 mg/kg) were studied in passive avoidance test. Effects of lithium (1mg/kg) on sumatriptan (10 mg/kg) -induced memory impairment were studied in both of tests. The present study demonstrated that sumatriptan impaired memory in Y-maze and passive avoidance tests (P<0.05, P<0.01, respectively). Lithium did not show any significant effect on memory function compared to salinetreated control group in both tests (P>0.05), but significantly reversed sumatriptan-induced memory impairment in Y-maze and passive avoidance tests (P<0.001, P<0.05, respectively). It is concluded that lithium reverses the sumatriptan-induced memory impairment probably through 5-HT1B/1D receptors antagonism.

 
Keyword(s): LITHIUM, SUMATRIPTAN, 5-HT1B/1D, SPATIAL RECOGNITION MEMORY, MICE
 
 
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APA: Copy

NIKOUI, V., & JAVADI PAYDAR, M., & SALEHI, M., & BEHESTANI, S., & DEHPOUR, A. (2016). PROTECTIVE EFFECTS OF LITHIUM ON SUMATRIPTAN-INDUCED MEMORY IMPAIRMENT IN MICE. ACTA MEDICA IRANICA, 54(4), 226-232. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511187



Vancouver: Copy

NIKOUI VAHID, JAVADI PAYDAR MEHRAK, SALEHI MAHTAB, BEHESTANI SELDA, DEHPOUR AHMAD REZA. PROTECTIVE EFFECTS OF LITHIUM ON SUMATRIPTAN-INDUCED MEMORY IMPAIRMENT IN MICE. ACTA MEDICA IRANICA. 2016 [cited 2021August04];54(4):226-232. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511187



IEEE: Copy

NIKOUI, V., JAVADI PAYDAR, M., SALEHI, M., BEHESTANI, S., DEHPOUR, A., 2016. PROTECTIVE EFFECTS OF LITHIUM ON SUMATRIPTAN-INDUCED MEMORY IMPAIRMENT IN MICE. ACTA MEDICA IRANICA, [online] 54(4), pp.226-232. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511187.



 
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