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Paper Information

Journal:   ACTA MEDICA IRANICA   2016 , Volume 54 , Number 4; Page(s) 245 To 250.
 
Paper: 

PELARGONIDIN IMPROVES PASSIVE AVOIDANCE TASK PERFORMANCE IN A RAT AMYLOID BETA25-35 MODEL OF ALZHEIMER’S DISEASE VIA ESTROGEN RECEPTOR INDEPENDENT PATHWAYS

 
 
Author(s):  SOHANAKI HAMID, BALUCHNEJADMOJARAD TOURANDOKHT*, NIKBAKHT FARNAZ, ROGHANI MEHRDAD
 
* DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, IRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Alzheimer’s disease (AD) is a disorder with multiple pathophysiological causes, destructive outcomes, and no available definitive cure. Pelargonidin (Pel), an anthocyanin derivative, is an estrogen receptor agonist with little estrogen side effects. This study was designed to assess Pel memory enhancing effects on the a rat Amyloid Beta25-35 (Ab) intrahippocampal microinjections model of AD in the passive avoidance task performance paradigm and further evaluate the potential estrogen receptor role on the memory-evoking compound. Equally divided rats were assigned to 5 groups of sham, Ab intrahippocampal microinjected, Pel pretreated (10 mg/kg, P.O), a estrogen antagonist intra-cerebrovascular (i.c.v.) microinjected, and b estrogen antagonist (i.c.v) microinjected animals. Intrahippocampal microinjections of Ab were adopted to provoke AD model. Passive avoidance task test was also used to assess memory performance. Pel pretreatment prior to Ab microinjections significantly improved step-through latency (P<0.001) in passive avoidance test. In a and b estrogen, antagonists received animals, passive avoidance task performance was not statistically changed (P=0.11 & P=0.41 respectively) compared to Pel pretreated and sham animals. Our results depicted that Pel improves Ab induced memory dysfunction in passive avoidance test performance through estrogen receptor independently related pathways.

 
Keyword(s): ALZHEIMER’S DISEASE, HIPPOCAMPUS, PELARGONIDIN, MEMORY DYSFUNCTION, PASSIVE AVOIDANCE TEST, ESTROGEN RECEPTOR
 
References: 
 
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