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Paper Information

Journal:   ARCHIVES OF CLINICAL INFECTIOUS DISEASES   JULY 2016 , Volume 11 , Number 3; Page(s) 0 To 0.
 
Paper: 

INVASIVE PULMONARY ASPERGILLOSIS IN PATIENTS WITH NON-DECOMPENSATED LIVER CIRRHOSIS: A CASE REPORT

 
 
Author(s):  GHASEMIAN ROYA, NOSRATI ANAHITA, NABILI MOJTABA, SHOKOHI TAHEREH*
 
* DEPARTMENT OF MEDICAL MYCOLOGY AND PARASITOLOGY/INVASIVE FUNGI RESEARCH CENTER, SCHOOL OF MEDICINE, MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, SARI, I.R. IRAN
 
Abstract: 

Introduction: Invasive pulmonary aspergillosis (IPA) is a fatal disease usually occurring in patients with neutropenia resulted from chemotherapy for malignancy. The other risk factors include consuming corticosteroids, organ transplant and advanced acquired immunodeficiency syndrome (AIDS). Recently, the incidence of IPA in immunocompetent patients without any history of organ transplant or malignancy has been increasing. Patients with advanced cirrhosis are one of the cases involved in this infection.
Case Presentation: In this case study, we report invasive pulmonary aspergillosis in a 50-year-old patient (from Sari, Iran), who had gradual abdominal pain and ascites, cough and respiratory distress. Radiographic signs showed a round infiltration in the upper part of the right lung. Despite receiving 48-hour antibiotics therapy, the fever had not subsided. In CT-guided needle lung biopsy, septate and acutely angled hyphae (dichotomous) were seen. In CT-guided needle lung biopsy, septate and acutely angled hyphae (dichotomous) were seen. Direct examination of the sputum showed septate hyphae compatible with a filamentous fungus. According to morphologicalandmolecular characterization, Aspergillus fumigatus wasconfirmed. Minimuminhibitory concentration (MIC) values of antifungal agents were determined based on the clinical and laboratory standard institute (CLSI) M38-A2. Treatment with intravenous amphotericin B was changed to oral voriconazole 200 mg, twice a day. The patient did not have any kind of residual lung lesion within the six-month follow-up and the cirrhosis was under control and she currently has no respiratory symptoms or signs.
Conclusions: In patients with liver cirrhosis, when there is evidence of severe pulmonary disease without proper response to treatment, the possibility of invasive pulmonary fungal infection should be considered.

 
Keyword(s): INVASIVE PULMONARY ASPERGILLOSIS (IPA), CIRRHOSIS, LIVER FAILURE
 
 
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APA: Copy

GHASEMIAN, R., & NOSRATI, A., & NABILI, M., & SHOKOHI, T. (2016). INVASIVE PULMONARY ASPERGILLOSIS IN PATIENTS WITH NON-DECOMPENSATED LIVER CIRRHOSIS: A CASE REPORT. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, 11(3), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511175



Vancouver: Copy

GHASEMIAN ROYA, NOSRATI ANAHITA, NABILI MOJTABA, SHOKOHI TAHEREH. INVASIVE PULMONARY ASPERGILLOSIS IN PATIENTS WITH NON-DECOMPENSATED LIVER CIRRHOSIS: A CASE REPORT. ARCHIVES OF CLINICAL INFECTIOUS DISEASES. 2016 [cited 2021July30];11(3):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511175



IEEE: Copy

GHASEMIAN, R., NOSRATI, A., NABILI, M., SHOKOHI, T., 2016. INVASIVE PULMONARY ASPERGILLOSIS IN PATIENTS WITH NON-DECOMPENSATED LIVER CIRRHOSIS: A CASE REPORT. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, [online] 11(3), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511175.



 
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