Paper Information

Journal:   ARCHIVES OF CLINICAL INFECTIOUS DISEASES   JULY 2016 , Volume 11 , Number 3; Page(s) 0 To 0.
 
Paper: 

REVIEW ARTICLE: EPSTEIN-BARR VIRUS INFECTION AND RISK OF BREAST CANCER: AN ADAPTIVE META-ANALYSIS FOR CASE-CONTROL STUDIES

 
 
Author(s):  BAE JONG MYON*, KIM EUN HEE
 
* DEPARTMENT OF PREVENTIVE MEDICINE, JEJU NATIONAL UNIVERSITY SCHOOL OF MEDICINE, JEJU-DO, KOREA
 
Abstract: 

Context: The association between ’Epstein-Barr’ virus (EBV) and breast cancer risk still remains controversial. ASystemic Review (SR) published in 2012 reported that there might be a statistically significant association between EBV and risk of breast cancer. However, errors were found in the appraisal process of the concerned SR.
Objectives: The aim of this report was to conduct an adaptive meta-analysis with additional extraction of relevant papers published up until September 2015.
Data Sources: The lists of references, cited articles and related articles provided by PubMed were made using the articles selected in the previous SR.
Study Selection: Among these articles, only case-control studies using Polymerase Chain Reaction (PCR) techniques to detect EBV DNA in tissues were selected.
Data Extraction: The summary odds ratio (SOR) and the 95% confidence interval (CI) were calculated though meta- analysis.
Results: A total of 20 case-control studies were selected, and the total numbers of subjects in the case and control groups were 1947 and 1010, respectively. The findings of this meta-analysis revealed that EBV infection might increase the risk of breast cancer (SOR =3.84, 95% CI: 2.24-6.58; I-squared=62.2%). Sub-group analyses by region, sample type, and control tissue showed that a statistical significance of the risk was still secured.
Conclusions: The findings of the meta-epidemiological study support that EBV infection may increase the risk of breast cancer.
Nested case-control studies are required in the future.

 
Keyword(s): BREAST NEOPLASMS, RISK FACTOR, EPSTEIN-BARR VIRUS, META-ANALYSIS
 
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