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Paper Information

Journal:   ARCHIVES OF CLINICAL INFECTIOUS DISEASES   APRIL 2016 , Volume 11 , Number 2; Page(s) 0 To 0.
 
Paper: 

BRIEF REPORT: RESISTANCE RATE AND MINIMUM INHIBITORY CONCENTRATION OF METRONIDAZOLE AMONGHELICOBACTER PYLORI STRAINS IN TEHRAN, IRAN

 
 
Author(s):  SHAHABIMEHR MAHNAZ, ALEBOUYEH MASOUD*, FARZI NASTARAN, MAHBOUBI ARASH, TASLIMI REZA, ZALI MOHAMMAD REZA
 
* GASTROENTEROLOGY AND LIVER DISEASES RESEARCH CENTER, RESEARCH INSTITUTE FOR GASTROENTEROLOGY AND LIVER DISEASE, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, I.R. IRAN
 
Abstract: 

Background: Constant monitoring of Helicobacter pylori resistance is necessary for selection of the best treatment regimen for eradication of the resistant strains.
Objectives: The aim of this study was to investigate diversity of resistance and minimum inhibitory concentration (MIC) of H. pylori strains against metronidazole in Tehran, Iran.
Patients and Methods: This cross-sectional study was performed among 96 patients, who had undergone gastric endoscopy at Imam Khomeini hospital in Tehran, during years 2013 to 2014.
Helicobacter pylori isolates were obtained from gastric biopsy samples on selective culture media after characterization by conventional biochemical tests and polymerase chain reaction. Minimum inhibitory concentration of metronidazole was determined by the agar dilution method.
Results: Helicobacter pylori infection was detected in 22 patients (22.92%). Identity of the isolates was confirmed by PCR using glmM primers. Chronic gastritis, duodenitis, intestinal metaplasia, dysplasia and cancer were detected among 70.1%, 6.25%, 1.04%, 1.4% and 10.41% of the patients, respectively. Smoking showed a negative relationship withH. pylori infection. The rate of antibiotic resistance was 81.8% (18.22) and MIC ranges of 8 to 512
mg/mL were detected. Furthermore, MIC50 and MIC90 were determined as 256 and 512 mg/mL, respectively.
Conclusions: In conclusion, these results suggested a need for a switch to second line therapy regimens for treatment of infected patients in the Iranian population.

 
Keyword(s): MICROBIAL SENSITIVITY TESTS, METRONIDAZOLE, HELICOBACTER PYLORI INFECTION
 
 
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APA: Copy

SHAHABIMEHR, M., & ALEBOUYEH, M., & FARZI, N., & MAHBOUBI, A., & TASLIMI, R., & ZALI, M. (2016). BRIEF REPORT: RESISTANCE RATE AND MINIMUM INHIBITORY CONCENTRATION OF METRONIDAZOLE AMONGHELICOBACTER PYLORI STRAINS IN TEHRAN, IRAN. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, 11(2), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511145



Vancouver: Copy

SHAHABIMEHR MAHNAZ, ALEBOUYEH MASOUD, FARZI NASTARAN, MAHBOUBI ARASH, TASLIMI REZA, ZALI MOHAMMAD REZA. BRIEF REPORT: RESISTANCE RATE AND MINIMUM INHIBITORY CONCENTRATION OF METRONIDAZOLE AMONGHELICOBACTER PYLORI STRAINS IN TEHRAN, IRAN. ARCHIVES OF CLINICAL INFECTIOUS DISEASES. 2016 [cited 2021July23];11(2):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511145



IEEE: Copy

SHAHABIMEHR, M., ALEBOUYEH, M., FARZI, N., MAHBOUBI, A., TASLIMI, R., ZALI, M., 2016. BRIEF REPORT: RESISTANCE RATE AND MINIMUM INHIBITORY CONCENTRATION OF METRONIDAZOLE AMONGHELICOBACTER PYLORI STRAINS IN TEHRAN, IRAN. ARCHIVES OF CLINICAL INFECTIOUS DISEASES, [online] 11(2), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511145.



 
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