Introduction: Cryptococcal meningitis is a rare disorder that is caused by Cryptococcus neoformans in immunocompromised host.
Case Presentation: The case was a 64-year-oldmanwith a history of stem cell transplant for acute leukemia, whopresented chronic meningitis caused by Cryptococcus neoformans and concurrent neoplastic meningitis with presence of malignant cells only in his cerebrospinal fluid (CSF).
Conclusions: Chronic meningitis in immunocompromised hosts can be due to more than one pathologic etiology and we should do all diagnostic evaluation to rule out all possible differential diagnosis.