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Paper Information

Journal:   MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)   JULY 2016 , Volume 8 , Number 3; Page(s) 257 To 261.
 
Paper: 

CASE REPORT: UPPER GASTROINTESTINAL BLEEDING AS THE FIRST MANIFESTATION OF WEGENER’S GRANULOMATOSIS

 
 
Author(s):  TAVAKOLI HAMID, ZOBEIRI MEHDI*, SALESI MANSOUR, SANEI MOHAMMAD HOSSEIN
 
* ZACARIA RAZI BOULEVARD, IMAM REZA HOSPITAL, KERMANSHAH, IRAN, POST CODE: 6714415333
 
Abstract: 

Wegener’s granulomatosis is an uncommon inflammatory disease that manifests as vasculitis, granulomatosis, and necrosis. It usually involves the upper and lower respiratory tracts and kidneys. Although it may essentially involve any organ, gastrointestinal (GI) involvement is notably uncommon.
A 20-year-old male patient presented with epigastric pain, vomiting, hematemesis, and melena. On physical examination, he was pale. There was no abdominal tenderness or organomegaly. Upper GI endoscopy revealed dark blue-colored infiltrative lesions in prepyloric area. Evaluation of the biopsy sample showed mononuclear cell infiltration in the submucosal area, hyperplastic polyp, and chronic gastritis. High dose proton pump inhibitor and adjunctive supportive measures were given but no change in the follow-up endoscopy was detected. During hospital course, he developed intermittent fever and serum creatinine elevation.12 days after admission, he developed dyspnea, tachypnea, and painful swelling of metacarpophalangeal joints, and maculopapular rash in extensor surface of the right forearm. Chest radiography showed pulmonary infiltration. Serum c-ANCA titer was strongly positive and skin biopsy revealed leukocytoclastic vasculitis. The patient received methylprednisolone pulse, which resulted in complete recovery of symptoms and gastric lesion.
The present case indicates that GI bleeding may be the first manifestation of Wegener’s granulomatosis. Moreover, it should be emphasized that gastric biopsy is not characteristic or diagnostic in such patients.

 
Keyword(s): WEGENER’S GRANULOMATOSIS, GASTROINTESTINAL SYMPTOMS, VASCULITIS, ANCA
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

TAVAKOLI, H., & ZOBEIRI, M., & SALESI, M., & SANEI, M. (2016). CASE REPORT: UPPER GASTROINTESTINAL BLEEDING AS THE FIRST MANIFESTATION OF WEGENER’S GRANULOMATOSIS. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 8(3), 257-261. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511089



Vancouver: Copy

TAVAKOLI HAMID, ZOBEIRI MEHDI, SALESI MANSOUR, SANEI MOHAMMAD HOSSEIN. CASE REPORT: UPPER GASTROINTESTINAL BLEEDING AS THE FIRST MANIFESTATION OF WEGENER’S GRANULOMATOSIS. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD). 2016 [cited 2021July25];8(3):257-261. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511089



IEEE: Copy

TAVAKOLI, H., ZOBEIRI, M., SALESI, M., SANEI, M., 2016. CASE REPORT: UPPER GASTROINTESTINAL BLEEDING AS THE FIRST MANIFESTATION OF WEGENER’S GRANULOMATOSIS. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), [online] 8(3), pp.257-261. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511089.



 
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