Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)   JULY 2016 , Volume 8 , Number 3; Page(s) 201 To 210.
 
Paper: 

THE EFFECT OF PROBIOTIC PLUS PREBIOTIC SUPPLEMENTATION ON THE TOLERANCE AND EFFICACY OF HELICOBACTER PYLORI ERADICATION QUADRUPLE THERAPY: A RANDOMIZED PROSPECTIVE DOUBLE BLIND CONTROLLED TRIAL

 
 
Author(s):  SHAFAGHI AFSHIN, POURKAZEMI AYDIN*, KHOSRAVANI MOHSEN, FAKHRIEH ASL SABA, AMIR MAAFI ALIREZA, ATRKAR ROSHAN ZAHRA, ABASPOUR RAHIMABAD JAFAR
 
* AZI HOSPITAL, SARDAR JANGAL ST., RASHT, GUILAN, IRAN, POSTAL CODE: 41448-95655
 
Abstract: 

BACKGROUND Standard anti-Helicobacter pylori (H. pylori) treatment fails in the eradication of the organism in almost 10-35% of the patients and has different side effects. Recent studies have proposed that probiotic supplementations with or without prebiotic may improve the eradication rate and diminish the side effects, although it is still a controversial issue. We aimed to investigate the effect of probiotic with prebiotic supplementation on the eradication rate and side effects of antiH. pylori quadruple therapy.
METHODS 76 patients with a positive biopsy specimen forH. pylori were enrolled.
They were randomized to receive quadruple therapy of bismuth, clarithromycin, amoxicillin, and omeprazole for 14 days and also the synbiotic or the placebo.
We asked them to answer study questionnaires at the beginning and during the treatment. Finally, urea breath test was done 8 weeks after the treatment.
RESULTS The eradication rate was significantly better in the synbiotic group by intention-to-treat analysis (p<0.05). Treatment side effects such as diarrhea, nausea, vomiting, epigastric pain, flatulence, constipation, and taste abnormality were similar in both groups but anorexia was significantly better in the synbiotic group (p<0.05).
CONCLUSION The eradication rate was significantly better in the synbiotic group by intention-to-treat analysis (p<0.05). Treatment side effects such as diarrhea, nausea, vomiting, epigastric pain, flatulence, ut could improve the eradication by augmenting the treatment tolerance and compliance.

 
Keyword(s): ERADICATION, H. PYLORI, PROBIOTIC, PREBIOTIC, SYNBIOTIC, QUADRUPLE THERAPY 201
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

SHAFAGHI, A., & POURKAZEMI, A., & KHOSRAVANI, M., & FAKHRIEH ASL, S., & AMIR MAAFI, A., & ATRKAR ROSHAN, Z., & ABASPOUR RAHIMABAD, J. (2016). THE EFFECT OF PROBIOTIC PLUS PREBIOTIC SUPPLEMENTATION ON THE TOLERANCE AND EFFICACY OF HELICOBACTER PYLORI ERADICATION QUADRUPLE THERAPY: A RANDOMIZED PROSPECTIVE DOUBLE BLIND CONTROLLED TRIAL. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 8(3), 201-210. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511067



Vancouver: Copy

SHAFAGHI AFSHIN, POURKAZEMI AYDIN, KHOSRAVANI MOHSEN, FAKHRIEH ASL SABA, AMIR MAAFI ALIREZA, ATRKAR ROSHAN ZAHRA, ABASPOUR RAHIMABAD JAFAR. THE EFFECT OF PROBIOTIC PLUS PREBIOTIC SUPPLEMENTATION ON THE TOLERANCE AND EFFICACY OF HELICOBACTER PYLORI ERADICATION QUADRUPLE THERAPY: A RANDOMIZED PROSPECTIVE DOUBLE BLIND CONTROLLED TRIAL. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD). 2016 [cited 2021August04];8(3):201-210. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511067



IEEE: Copy

SHAFAGHI, A., POURKAZEMI, A., KHOSRAVANI, M., FAKHRIEH ASL, S., AMIR MAAFI, A., ATRKAR ROSHAN, Z., ABASPOUR RAHIMABAD, J., 2016. THE EFFECT OF PROBIOTIC PLUS PREBIOTIC SUPPLEMENTATION ON THE TOLERANCE AND EFFICACY OF HELICOBACTER PYLORI ERADICATION QUADRUPLE THERAPY: A RANDOMIZED PROSPECTIVE DOUBLE BLIND CONTROLLED TRIAL. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), [online] 8(3), pp.201-210. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511067.



 
  pdf-File
Yearly Visit 74
 
 
Latest on Blog
Enter SID Blog