Paper Information

Journal:   JOURNAL OF OPHTHALMIC AND VISION RESEARCH   2016 , Volume 11 , Number 1; Page(s) 54 To 60.
 
Paper: 

ASSOCIATION OF AGE RELATED MACULAR DEGENERATION AND AGE RELATED HEARING IMPAIRMENT

 
DOI: 

10.4103/2008-322X.180699

 
Author(s):  GHASEMI HASSAN, SHAHIDI POURAKBARI MALIHE, ENTEZARI MORTEZA, YARMOHAMMADI MOHAMMAD EBRAHIM*
 
* DEPARTMENT OF OTOLARYNGOLOGY, SCHOOL OF MEDICINE, SHAHED UNIVERSITY OF MEDICAL SCIENCES, TEHRAN 14155, IRAN
 
Abstract: 

Purpose: To evaluate the association between age?related macular degeneration (ARMD) and sensory neural hearing impairment (SHI).
Methods: In this case?control study, hearing status of 46 consecutive patients with ARMD were compared with 46 age?matched cases without clinical ARMD as a control group. In all patients, retinal involvements were confirmed by clinical examination, fluorescein angiography (FA) and optical coherence tomography (OCT). All participants were examined with an otoscope and underwent audiological tests including pure tone audiometry (PTA), speech reception threshold (SRT), speech discrimination score (SDS), tympanometry, reflex tests and auditory brainstem response (ABR).
Results: A significant (P=0.009) association was present between ARMD, especially with exudative and choroidal neovascularization (CNV) components, and age?related hearing impairment primarily involving high frequencies. Patients had higher SRT and lower SDS against anticipated presbycusis than control subjects. Similar results were detected in exudative, CNV and scar patterns supporting an association between late ARMD with SRT and SDS abnormalities. ABR showed significantly prolonged wave I and IV latency times in ARMD (P=0.034 and 0.022, respectively). Average latency periods for wave I in geographic atrophy (GA) and CNV, and that for wave IV in drusen patterns of ARMD were significantly higher than controls (P=0.030, 0.007 and 0.050, respectively).
Conclusion: The association between ARMD and age?related SHI may be attributed to common anatomical components such as melanin in these two sensory organs.

 
Keyword(s): AGE RELATED MACULAR DEGENERATION, SENSORY NEURAL HEARING IMPAIRMENT, RETINAL PIGMENT EPITHELIUM, PIGMENTARY DISORDER, MELANIN
 
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