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Paper Information

Journal:   MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)   APRIL 2016 , Volume 8 , Number 2; Page(s) 109 To 115.
 
Paper: 

AN ACCESSIBLE AND PRAGMATIC EXPERIMENTAL MODEL OF NONALCOHOLIC FATTY LIVER DISEASE

 
 
Author(s):  EMAMAT HADI, NOORI MARYAM, FOROUGHI FOROUGH, RISMANCHI MARJAN, EINI ZINAB HASSAN, HEKMATDOOST AZITA*
 
* DEPARTMENT OF CLINICAL NUTRITION AND DIETETICS, FACULTY OF NUTRITION SCIENCES AND FOOD TECHNOLOGY, NATIONAL NUTRITION AND FOOD TECHNOLOGY RESEARCH INSTITUTE, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

BACKGROUND: There is no convenient cheap pragmatic experimental model for Nonalcoholic Fatty Liver Disease (NAFLD) /Nonalcoholic Steatohepatitis (NASH). Objective: Our objective was to create a pragmatic model of NAFLD/NASH.
METHODS: Sprague-Dawley rats were fed a high-fat, high sugar homemade diet ad libitum for seven weeks. The high-fat, high sugar diet included 59% of energy derived from fat, 30% from carbohydrates, and 11% from protein. Serum levels of fasting glucose, triglyceride, cholesterol, liver enzymes, insulin, and hepatic tumor necrosis factor-alpha (TNF-
a) gene expression were determined. Hepatic histology was examined by H & E stain.
RESULTS: Rats fed the high-fat, high sugar diet developed hepatic steatosis, and a moderate inflammation, which was associated with increased serum levels of liver enzymes, glucose, insulin, triglyceride, cholesterol, and hepatic TNF-
a gene expression.
CONCLUSION: This rat model resembles the key features of human NAFLD/NASH and provides a simple pragmatic experimental model for elucidating the disease prevention and treatment.

 
Keyword(s): EXPERIMENTAL MODEL, NAFLD, NASH, RAT, NONALCOHOLIC FATTY LIVER DISEASE, DIET
 
 
References: 
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Citations: 
 
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APA: Copy

EMAMAT, H., & NOORI, M., & FOROUGHI, F., & RISMANCHI, M., & EINI ZINAB, H., & HEKMATDOOST, A. (2016). AN ACCESSIBLE AND PRAGMATIC EXPERIMENTAL MODEL OF NONALCOHOLIC FATTY LIVER DISEASE. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 8(2), 109-115. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511034



Vancouver: Copy

EMAMAT HADI, NOORI MARYAM, FOROUGHI FOROUGH, RISMANCHI MARJAN, EINI ZINAB HASSAN, HEKMATDOOST AZITA. AN ACCESSIBLE AND PRAGMATIC EXPERIMENTAL MODEL OF NONALCOHOLIC FATTY LIVER DISEASE. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD). 2016 [cited 2021August04];8(2):109-115. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511034



IEEE: Copy

EMAMAT, H., NOORI, M., FOROUGHI, F., RISMANCHI, M., EINI ZINAB, H., HEKMATDOOST, A., 2016. AN ACCESSIBLE AND PRAGMATIC EXPERIMENTAL MODEL OF NONALCOHOLIC FATTY LIVER DISEASE. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), [online] 8(2), pp.109-115. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511034.



 
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