Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   JUNE 2016 , Volume 19 , Number 6; Page(s) 426 To 429.
 
Paper: 

PLATELET TRANSFUSION OUTCOME AND FLOW CYTOMETRIC MONOCYTE PHAGOCYTIC ASSAY (FMPA)

 
DOI: 

0161906/AIM.0010

 
Author(s):  SAYYADI MOHAMMAD, SHAIEGAN MOJGAN*, NIKOUGOFTAR ZARIF MAHIN, VAEZI MOHAMMAD, MOHAMMADI SAEED
 
* BLOOD TRANSFUSION RESEARCH CENTER, HIGH INSTITUTE FOR RESEARCH AND EDUCATION IN TRANSFUSION MEDICINE, TEHRAN, IRAN
 
Abstract: 

BACKGROUND: This study was designed to evaluate platelet transfusion outcome via flow cytometric monocyte phagocytic assay (FMPA).
METHODS: Fifteen patients with a history of multiple platelet transfusions and fifteen controls were enrolled in this study. CMFDA-labeled platelets were incubated with patients' sera and were finally incubated with monocytes in a tube and analyzed by flow cytometry. Monocytes that phagocytosed platelets were detected as a CMFDA-positive platelet population via monocyte gate. The FMPA results were compared with CCI results for the patients.
RESULTS: The FMPA result correlated with 1-hour (r=-0.885, P=0.001) and 24-hour (r=-0.884, P=0.001) CCI. There is a significant difference in means of FMPA results between the patients with immune platelet refractoriness (68.46±10.4%), non-refractory group (37.73±15.21%) and the control group (18.27±2.86%).
CONCLUSION: Our data showed that FMPA has good results in evaluation of platelet transfusion outcome and may be useful as an indicator of platelet transfusion response.

 
Keyword(s): CMFDA, FLOW CYTOMETRY, FMPA, PLATELET TRANSFUSION
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

SAYYADI, M., & SHAIEGAN, M., & NIKOUGOFTAR ZARIF, M., & VAEZI, M., & MOHAMMADI, S. (2016). PLATELET TRANSFUSION OUTCOME AND FLOW CYTOMETRIC MONOCYTE PHAGOCYTIC ASSAY (FMPA). ARCHIVES OF IRANIAN MEDICINE, 19(6), 426-429. https://www.sid.ir/en/journal/ViewPaper.aspx?id=511015



Vancouver: Copy

SAYYADI MOHAMMAD, SHAIEGAN MOJGAN, NIKOUGOFTAR ZARIF MAHIN, VAEZI MOHAMMAD, MOHAMMADI SAEED. PLATELET TRANSFUSION OUTCOME AND FLOW CYTOMETRIC MONOCYTE PHAGOCYTIC ASSAY (FMPA). ARCHIVES OF IRANIAN MEDICINE. 2016 [cited 2021July27];19(6):426-429. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511015



IEEE: Copy

SAYYADI, M., SHAIEGAN, M., NIKOUGOFTAR ZARIF, M., VAEZI, M., MOHAMMADI, S., 2016. PLATELET TRANSFUSION OUTCOME AND FLOW CYTOMETRIC MONOCYTE PHAGOCYTIC ASSAY (FMPA). ARCHIVES OF IRANIAN MEDICINE, [online] 19(6), pp.426-429. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=511015.



 
  pdf-File
Yearly Visit 56
 
 
Latest on Blog
Enter SID Blog