Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   JULY 2016 , Volume 19 , Number 7; Page(s) 508 To 517.
 
Paper: 

THE ROLE OF LONG NON-CODING RNAS IN BREAST CANCER

 
DOI: 

0161907/AIM.0011

 
Author(s):  SOUDYAB MOHAMMAD, IRANPOUR MOSTAFA, GHAFOURI FARD SOUDEH*
 
* DEPARTMENT OF MEDICAL GENETICS, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Long non-coding RNA (lncRNA) genes are an important population of non-coding RNAs with defined key roles in normal development as well as tumorigenesis process. Evidences suggest that they can be classified as tumor suppressor genes or oncogenes according to their functions and expression pattern in tumoral tissues. They have been shown to regulate the plasticity of cancer stem cells. Their important roles in the regulation of cancer-related pathways in addition to deregulation of their expression in a number of cancers have suggested that they can be used as markers for cancer detection and prognosis, as well as targets for cancer treatment. Deregulation of a number of lncRNAs, such as HOTAIR, XIST, MALAT, and H19 has been detected in breast cancer samples and cell lines. In addition, the association between lncRNAs signature and breast cancer patients’ survival has been assessed in various studies. Here, the expression patterns of lncRNAs in breast cancer, as well as their significance in prognosis and patient treatment are discussed.

 
Keyword(s): BREAST CANCER, LONG NON-CODING RNA, PROGNOSIS
 
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