Paper Information

Journal:   NOVELTY IN BIOMEDICINE   2016 , Volume 4 , Number 3; Page(s) 100 To 104.
 
Paper: 

EFFECT OF POLY LACTIC-CO-GLYCOLIC ACID-IBUPROFEN ON ICAM-1 AND VCAM-1 EXPRESSION IN A MICE ADHESION MODEL

 
 
Author(s):  JAMSHIDI ADEGANI FATEMEH, SEYEDJAFARI EHSAN, GHEIBI NEMATOLLAH, DODEL MASUMEH, MOHAMMADI SANGCHESHMEH ABDOLLAH, SOLEIMANI MASOUD*, SAHMANI MEHDI*
 
* DEPARTMENT OF CLINICAL BIOCHEMISTRY, CELLULAR AND MOLECULAR RESEARCH CENTER, QAZVIN UNIVERSITY OF MEDICAL SCIENCES, QAZVIN, IRAN
 
Abstract: 

Background: In this study, we compared the effect of ibuprofen (IB) while incorporating by Poly Lactic-co-Glycolic Acid (PLGA) nanofiber on expression of adhesion molecules ICAM-1 and VCAM-1 in a mice adhesion model.
Materials and Methods: Using an adhesion model were induced in mice, PLGA-IB and PLGA membranes and IB were sutured between the abdominal wall and peritoneum after surgical operation to reveal the best membrane for prevention of postoperative adhesion bands by comparison of ICAM-1 and VCAM-1 expression.
Results: Compared with other groups, PLGA-IB showed a greater ability to reduce ICAM-1 and VCAM-1 expression.
Conclusion: These results suggested that in considering the FDA approved polymers, PLGA-IB could be introduced as a potential candidate for prevention of abdominal post-surgery inflammation and adhesion band formation after surgeries.

 
Keyword(s): INTRAPERITONEAL ADHESION, PLGA, IBUPROFEN, ICAM-1, VCAM-1
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 62
 
Latest on Blog
Enter SID Blog