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Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   1ST WEEK AUGUST 2016 , Volume 34 , Number 385; Page(s) 649 To 656.
 
Paper: 

EVALUATION OF RELATIVE FREQUENCY OF SINGLE NUCLEOTIDE POLYMORPHISM G870A (RS9344) IN CYCLIND1 GENE IN COLORECTAL CANCER PATIENTS AND HEALTHY SUBJECTS OF ISFAHAN PROVINCE, IRAN

 
 
Author(s):  RAHIMIRAD SHIMA, SALEHI RASOUL*, SAFFAR BEHNAZ, NIAEE MOSTAFA
 
* DEPARTMENT OF GENETICS AND MOLECULAR BIOLOGY, SCHOOL OF MEDICINE, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: Colorectal cancer (CRC) is one of the most common cancers in the world. High activity of CyclinD1 gene has been seen in the progress of this cancer. A common polymorphism (G870A) in exon 4 of CyclinD1 produces a variant transcript with longer half-life and may cause uncontrollable cellular growth thus contributing to cancer development. This study was performed to evaluate the frequency of CCND1 G870A polymorphism between CRC cases and controls.
Methods: DNA samples from peripheral blood leukocytes of 50 patients with sporadic colorectal cancer and 50 healthy subjects were extracted. CCND1 G870A polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in healthy subjects and patients. Statistical analysis was performed by chi-squared test via SPSS software.
Findings: Relationship between CCND1 G870A polymorphism in allele frequencies between cases and controls were not observed (P=0.204). While the frequency of AA genotype was significantly higher in patients (P=0.040, 95% CI=1.13-5.54, OR=2.25).
Conclusion: According to the significant association observed between certain genotypes of this locus (AA) with colorectal cancer, it can be used in the future as a good prognostic marker in CRC screening programs.

 
Keyword(s): COLORECTAL CANCER, SINGLE NUCLEOTIDE POLYMORPHISM, CYCLIN D1 GENE
 
 
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APA: Copy

RAHIMIRAD, S., & SALEHI, R., & SAFFAR, B., & NIAEE, M. (2016). EVALUATION OF RELATIVE FREQUENCY OF SINGLE NUCLEOTIDE POLYMORPHISM G870A (RS9344) IN CYCLIND1 GENE IN COLORECTAL CANCER PATIENTS AND HEALTHY SUBJECTS OF ISFAHAN PROVINCE, IRAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 34(385), 649-656. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510834



Vancouver: Copy

RAHIMIRAD SHIMA, SALEHI RASOUL, SAFFAR BEHNAZ, NIAEE MOSTAFA. EVALUATION OF RELATIVE FREQUENCY OF SINGLE NUCLEOTIDE POLYMORPHISM G870A (RS9344) IN CYCLIND1 GENE IN COLORECTAL CANCER PATIENTS AND HEALTHY SUBJECTS OF ISFAHAN PROVINCE, IRAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S). 2016 [cited 2021September20];34(385):649-656. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510834



IEEE: Copy

RAHIMIRAD, S., SALEHI, R., SAFFAR, B., NIAEE, M., 2016. EVALUATION OF RELATIVE FREQUENCY OF SINGLE NUCLEOTIDE POLYMORPHISM G870A (RS9344) IN CYCLIND1 GENE IN COLORECTAL CANCER PATIENTS AND HEALTHY SUBJECTS OF ISFAHAN PROVINCE, IRAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), [online] 34(385), pp.649-656. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510834.



 
 
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