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Paper Information

Journal:   IRANIAN JOURNAL OF MICROBIOLOGY   FEBRUARY 2016 , Volume 8 , Number 1; Page(s) 62 To 69.
 
Paper: 

EMERGENCE OF COLISTIN RESISTANT PSEUDOMONAS AERUGINOSA AT TABRIZ HOSPITALS, IRAN

 
 
Author(s):  GOLI HAMIDREZA, NAHAEI MOHAMMAD REZA, AHANGARZADEH REZAEE MOHAMMAD, HASANI ALKA, SAMADI KAFIL HOSSEIN, AGHAZADEH MOHAMMAD*
 
* DRUG APPLIED RESEARCH CENTER, FACULTY OF MEDICINE, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Background and Objectives: The prevalence of multidrug resistant Pseudomonas aeruginosa is the main reason of new drugs resurgence such as colistin. The main objectives of this study were to determine the antibiotic resistance pattern and the rate of colistin resistance along with its correlation with overexpression of MexAB-OprM and MexXY-OprM efflux pumps among P. aeruginosa isolates.
Materials and Methods: Hundred clinical isolates were collected from 100 patients during 6 months in 2014. Susceptibility to the eight antibiotics was investigated using Kirby-Bauer and agar dilution methods. The Quantitative Real-time PCR was used to determine the expression levels of efflux genes.
Results: Resistance rates to various antibiotics were as follows: ticarcillin (73%), ciprofloxacin (65%), aztreonam (60%), ceftazidime (55%), gentamicin (55%), imipenem (49%), piperacillin/tazobactam (34%) and colistin (2%). In disk diffusion method, only two isolates were non susceptible to colistin, however in agar dilution method the two isolates were confirmed as resistant and two others were intermediate resistant. Sixty eight (68%) isolates were multi-drug resistant and 10 isolates were susceptible to all tested antibiotics. Both colistin resistant isolates showed overexpression of both efflux pumps, but two intermediate resistant isolates exhibited reduction of efflux genes expression.
Conclusions: Emergence of colistin resistance is increasing in P. aeruginosa indicating great challenge in the treatment of infections caused by MDR strains of this organism in Iran. ParRS may promote either induced or constitutive resistance to colistin through the activation of distinct mechanisms such as MDR ef?ux pumps, and LPS modi?cation.

 
Keyword(s): PSEUDOMONAS AERUGINOSA, MULTI DRUG RESISTANT, COLISTIN, MEXAB-OPRM, MEXXY-OPRM
 
 
References: 
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Citations: 
 
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APA: Copy

GOLI, H., & NAHAEI, M., & AHANGARZADEH REZAEE, M., & HASANI, A., & SAMADI KAFIL, H., & AGHAZADEH, M. (2016). EMERGENCE OF COLISTIN RESISTANT PSEUDOMONAS AERUGINOSA AT TABRIZ HOSPITALS, IRAN. IRANIAN JOURNAL OF MICROBIOLOGY, 8(1), 62-69. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510712



Vancouver: Copy

GOLI HAMIDREZA, NAHAEI MOHAMMAD REZA, AHANGARZADEH REZAEE MOHAMMAD, HASANI ALKA, SAMADI KAFIL HOSSEIN, AGHAZADEH MOHAMMAD. EMERGENCE OF COLISTIN RESISTANT PSEUDOMONAS AERUGINOSA AT TABRIZ HOSPITALS, IRAN. IRANIAN JOURNAL OF MICROBIOLOGY. 2016 [cited 2021July27];8(1):62-69. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510712



IEEE: Copy

GOLI, H., NAHAEI, M., AHANGARZADEH REZAEE, M., HASANI, A., SAMADI KAFIL, H., AGHAZADEH, M., 2016. EMERGENCE OF COLISTIN RESISTANT PSEUDOMONAS AERUGINOSA AT TABRIZ HOSPITALS, IRAN. IRANIAN JOURNAL OF MICROBIOLOGY, [online] 8(1), pp.62-69. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510712.



 
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