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Paper Information

Journal:   IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)   MAY 2016 , Volume 10 , Number 3; Page(s) 156 To 163.
 
Paper: 

EFFECTS OF GENETIC POLYMORPHISM IN CYP3A4 AND CYP3A5 GENES ON TACROLIMUS DOSE AMONG KIDNEY TRANSPLANT RECIPIENTS

 
 
Author(s):  YOUSEF AL MOTASSEM*, QOSA HISHAM, BULATOVA NAILYA R., ABUHALIEMA ALI, ALMADHOUN HUSSEIN, KHAYYAT GHADA, OLEMAT MUHAMMAD
 
* DEPARTMENT OF BIOPHARMACEUTICS AND CLINICAL PHARMACY, COLLEGE OF PHARMACY, UNIVERSITY OF JORDAN, AMMAN, JORDAN
 
Abstract: 

Introduction: This study aimed to evaluate the effects of single nucleotide polymorphismsCYP3A4*1B and CYP3A5*3 on tacrolimus dose requirement among kidney transplant recipients.
Materials and Methods: Blood levels of tacrolimus were measured using microparticle enzyme immunoassay. Genotyping analysis utilized specific polymerase chain reaction-restriction fragment length polymorphism methods for 137 kidney transplant recipients.
Results: The median tacrolimus dose was significantly lower in the CYP3A4*1/*1carriers (0.06 mg/kg/d; range, 0.007 mg/kg/d to 0.17 mg/kg/d) as compared to theCYP3A4*1B/*1B carriers (0.1 mg/ kg/d; range, 0.03 mg/kg/d to 0.22 mg/kg/d; P=.001). Patients with at least 1CYP3A5*1 wild-type allele required higher median doses of tacrolimus (median, 0.08 mg/kg/d; range, 0.03 mg/kg/d to 0.22 mg/kg/d) as compared to theCYP3A5*3 carriers (median, 0.05 mg/kg/d; range, 0.007 mg/kg/d to 0.17 mg/kg/d; P=.002).
Conclusions: This study showed that tacrolimus dose requirement is lower in Jordanian kidney transplant recipients compared to other populations. Moreover, we found a correlation between genetic variations inCYP3A4 and CYP3A5 enzymes and tacrolimus blood levels among our kidney transplant recipients.

 
Keyword(s): CYP3A, TACROLIMUS, POLYMORPHISM, KIDNEY TRANSPLANTATION
 
 
References: 
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APA: Copy

YOUSEF, A., & QOSA, H., & BULATOVA, N., & ABUHALIEMA, A., & ALMADHOUN, H., & KHAYYAT, G., & OLEMAT, M. (2016). EFFECTS OF GENETIC POLYMORPHISM IN CYP3A4 AND CYP3A5 GENES ON TACROLIMUS DOSE AMONG KIDNEY TRANSPLANT RECIPIENTS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 10(3), 156-163. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510646



Vancouver: Copy

YOUSEF AL MOTASSEM, QOSA HISHAM, BULATOVA NAILYA R., ABUHALIEMA ALI, ALMADHOUN HUSSEIN, KHAYYAT GHADA, OLEMAT MUHAMMAD. EFFECTS OF GENETIC POLYMORPHISM IN CYP3A4 AND CYP3A5 GENES ON TACROLIMUS DOSE AMONG KIDNEY TRANSPLANT RECIPIENTS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD). 2016 [cited 2021August02];10(3):156-163. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510646



IEEE: Copy

YOUSEF, A., QOSA, H., BULATOVA, N., ABUHALIEMA, A., ALMADHOUN, H., KHAYYAT, G., OLEMAT, M., 2016. EFFECTS OF GENETIC POLYMORPHISM IN CYP3A4 AND CYP3A5 GENES ON TACROLIMUS DOSE AMONG KIDNEY TRANSPLANT RECIPIENTS. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), [online] 10(3), pp.156-163. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510646.



 
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