Paper Information

Journal:   AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)   JULY-SEPTEMBER 2016 , Volume 8 , Number 3; Page(s) 120 To 125.
 
Paper: 

NEUROPROTECTIVE EFFECTS OF HERBAL EXTRACT (ROSA CANINA, TANACETUM VULGARE AND URTICA DIOICA) ON RAT MODEL OF SPORADIC ALZHEIMER’S DISEASE

 
 
Author(s):  DANESHMAND PARVANEH, SALIMINEJAD KIOOMARS, DEHGHAN SHASALTANEH MARZIEH, KAMALI KOOROSH, RIAZI GHOLAMHOSEIN, NAZARI REZA, AZIMZADEH PEDRAM, KHORRAM KHORSHID HAMID REZA*
 
* GENETIC RESEARCH CENTER, UNIVERSITY OF SOCIAL WELFARE AND REHABILITATION SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: Sporadic Alzheimer’s Disease (SAD) is caused by genetic risk factors, aging and oxidative stresses. The herbal extract ofRosa canina (R. canina), Tanacetum vulgare (T. vulgare)and Urtica dioica (U. dioica) has a beneficial role in aging, as an anti-inflammatory and anti-oxidative agent. In this study, the neuroprotective effects of this herbal extract in the rat model of SAD was investigated.
Methods: The rats were divided into control, sham, model, herbal extract -treated and ethanol-treated groups. Drug interventions were started on the 21st day after modeling and each treatment group was given the drugs by intraperitoneal (I.P.) route for 21 days. The expression levels of the five important genes for pathogenesis of SAD including Syp, Psen1, Mapk3, Map2 and Tnf-
a were measured by qPCR between the hippocampi of SAD model which were treated by this herbal extract and control groups. The Morris Water Maze was adapted to test spatial learning and memory ability of the rats.
Results: Treatment of the rat model of SAD with herbal extract induced a significant change in expression of Syp (p=0.001) and Psen1 (p=0.029). In Morris Water Maze, significant changes in spatial learning seen in the rat model group were improved in herbal-treated group.
Conclusion: This herbal extract could have anti-dementia properties and improve spatial learning and memory in SAD rat model.

 
Keyword(s): ALZHEIMER DISEASE, GENE EXPRESSION, HERBAL EXTRACT
 
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