Paper Information

Journal:   HEPATITIS MONTHLY   JUNE 2016 , Volume 16 , Number 6; Page(s) 0 To 0.
 
Paper: 

IMPROVEMENT IN THE AMINO ACID IMBALANCE IN HEPATITIS C VIRUS INFECTED PATIENTS AFTER VIRAL ERADICATION BY INTERFERON TREATMENT (BRIEF REPORT)

 
 
Author(s):  ENOMOTO HIRAYUKI*, NISHIKAWA HIROKI, IKEDA NAOTO, AIZAWA NOBUHIRO, SAKAI YOSHIYUKI, YOH KAZUNORI, TAKATA RYO, HASEGAWA KUNIHIRO, NAKANO CHIKAGE, NISHIMURA TAKASHI, ISHII AKIO, TAKASHIMA TOMOYUKI, IWATA YOSHINORI, IIJIMA HIROKO, NISHIGUCHI SHUHEI
 
* DIVISION OF HEPATOBILIARY AND PANCREATIC DISEASE, DEPARTMENT OF INTERNAL MEDICINE, HYOGO COLLEGE OF MEDICINE, NISHINOMIYA, HYOGO 663-8501, JAPAN
 
Abstract: 

Background: In patients with chronic liver diseases (CLDs), hepatitis C virus (HCV) infection in particular may cause various metabolic disorders. We previously reported that the value of the ratio of branched-chain amino acids to tyrosine (BTR) decreased with the progression of liver fibrosis.
Objectives: We investigated the changes in clinical variables during interferon (IFN) treatment and assessed whether HCV eradication improved the amino acid imbalance in HCV infected patients.
Patients and Methods: We retrospectively collected the clinical data of HCV-related CLD patients whose BTR values had been measured both pre- and post-IFN treatment. A total of 17 patients with a sustained viral response (SVR) (mean observational period: 1085.0 days) and 19 patients without an SVR (Non-SVR) (mean observational period: 1002.5 days) were studied.
Results: In patients with an SVR, the serum levels of aminotransferases were decreased after HCV eradication. Although general liver functional tests (albumin and total bilirubin) did not significantly change, the BTR values significantly increased. However, in patients without an SVR, an improvement in the BTR value was not observed after IFN treatment.
Conclusions: HCV eradication can improve the amino acid imbalance in HCV infected patients.

 
Keyword(s): HEPATITIS C VIRUS, INTERFERON, AMINO ACID
 
References: 
 
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