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Paper Information

Journal:   IRANIAN JOURNAL OF PEDIATRICS   JUNE 2016 , Volume 26 , Number 3; Page(s) 0 To 0.
 
Paper: 

DETERMINATION OF AGE-DEPENDENT REFERENCE RANGES FOR COAGULATION TESTS PERFORMED USING DESTINY PLUS

 
DOI: 

10.5812/ijp.6177

 
Author(s):  ARSLAN FATMA DEMET*, SERDAR MUHITTIN, ARI ELIF MERVE, OZTAN MUSTAFA ONUR, KOZCU SUREYYA HIKMET, TARHAN HUSEYIN, CAKMAK OZGUR, ZEYTINLI MERVE, ELLIDAG HAMIT YASAR
 
* DEPARTMENT OF MEDICAL BIOCHEMISTRY, TEPECIK TRAINING AND RESEARCH HOSPITAL, GAZILER STREET, IZMIR, TURKEY
 
Abstract: 

Background: In order to apply the right treatment for hemostatic disorders in pediatric patients, laboratory data should be interpreted with age-appropriate reference ranges.
Objectives: The purpose of this study was to determining age-dependent reference range values for prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen tests, and D-dimer tests.
Materials and Methods: A total of 320 volunteers were included in the study with the following ages: 1 month - 1 year (n=52), 2 - 5 years (n=50), 6 - 10 years (n=48), 11 - 17 years (n=38), and 18 - 65 years (n=132). Each volunteer completed a survey to exclude hemostatic system disorder. Using a nonparametric method, the lower and upper limits, including 95% distribution and 90% confidence intervals, were calculated.
Results: No statistically significant differences were found between PT and aPTT values in the groups consisting of children. Thus, the reference ranges were separated into child and adult age groups. PT and aPTT values were significantly higher in the children than in the adults. Fibrinogen values in the 6 - 10 age group and the adult age group were significantly higher than in the other groups. D-dimer levels were significantly lower in those aged 2 - 17; thus, a separate reference range was established.
Conclusions: These results support other findings related to developmental hemostasis, confirming that adult and pediatric age groups should be evaluated using different reference ranges.

 
Keyword(s): REFERENCE RANGES, AGE GROUPS, BLOOD COAGULATION TESTS
 
 
References: 
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Citations: 
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APA: Copy

ARSLAN, F., & SERDAR, M., & ARI, E., & OZTAN, M., & KOZCU, S., & TARHAN, H., & CAKMAK, O., & ZEYTINLI, M., & ELLIDAG, H. (2016). DETERMINATION OF AGE-DEPENDENT REFERENCE RANGES FOR COAGULATION TESTS PERFORMED USING DESTINY PLUS. IRANIAN JOURNAL OF PEDIATRICS, 26(3), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510574



Vancouver: Copy

ARSLAN FATMA DEMET, SERDAR MUHITTIN, ARI ELIF MERVE, OZTAN MUSTAFA ONUR, KOZCU SUREYYA HIKMET, TARHAN HUSEYIN, CAKMAK OZGUR, ZEYTINLI MERVE, ELLIDAG HAMIT YASAR. DETERMINATION OF AGE-DEPENDENT REFERENCE RANGES FOR COAGULATION TESTS PERFORMED USING DESTINY PLUS. IRANIAN JOURNAL OF PEDIATRICS. 2016 [cited 2021July24];26(3):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510574



IEEE: Copy

ARSLAN, F., SERDAR, M., ARI, E., OZTAN, M., KOZCU, S., TARHAN, H., CAKMAK, O., ZEYTINLI, M., ELLIDAG, H., 2016. DETERMINATION OF AGE-DEPENDENT REFERENCE RANGES FOR COAGULATION TESTS PERFORMED USING DESTINY PLUS. IRANIAN JOURNAL OF PEDIATRICS, [online] 26(3), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510574.



 
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