Paper Information

Journal:   IRANIAN JOURNAL OF PEDIATRICS   JUNE 2016 , Volume 26 , Number 3; Page(s) 0 To 0.
 
Paper: 

BILINEAL ACUTE LEUKEMIA ASSOCIATED WITH FANCONI SYNDROME: THE FIRST CASE REPORT

 
DOI: 

10.5812/ijp.3723

 
Author(s):  MIRI ALIABAD GHASEM*, HOSEINI MARYAM SADAT, DORGALALEH AKBAR
 
* DEPARTMENT OF PEDIATRICS, CHILDREN AND ADOLESCENT HEALTH RESEARCH CENTER, ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES, ZAHEDAN, I.R. IRAN
 
Abstract: 

Fanconi syndrome is a metabolic disorder involving dysfunction of the renal proximal tubules, resulting in excessive urinary excretion of several metabolites. Various factors may lead to Fanconi syndrome, as it may be a genetic disease with primary or secondary etiologies, or may be acquired. In this study, we report a unique case of Fanconi syndrome with development of a relatively rare acute leukemia, a condition that has not been reported before. The case was an 8-year-old boy with familial occurrence of Fanconi syndrome, presenting with pallor, asthenia, recurrent infections, growth failure, and a variety of biochemical and hematological abnormalities. After physical examination, radiographic studies, and comprehensive laboratory analyses, Fanconi syndrome associated with bilineal acute leukemia, of myeloid and T-lymphoid lineages, was diagnosed.

 
Keyword(s): FANCONI SYNDROME, RENAL DYSFUNCTION, BILINEAL LEUKEMIA
 
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