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Paper Information

Journal:   HEPATITIS MONTHLY   2016 , Volume 16 , Number 4; Page(s) 0 To 0.
 
Paper: 

LEPTIN RECEPTOR GENE POLYMORPHISMS AND THE RISK OF NON-ALCOHOLIC FATTY LIVER DISEASE AND CORONARY ATHEROSCLEROSIS IN THE CHINESE HAN POPULATION

 
 
Author(s):  AN BAI QUAN, LU LIN LIN, YUAN CHEN, XIN YONG NING*, XUAN SHI YING*
 
* DEPARTMENT OF GASTROENTEROLOGY, QINGDAO MUNICIPAL HOSPITAL, QINGDAO, CHINA
 
Abstract: 

Background: Leptin receptor (LEPR) polymorphisms have been reported to be associated with lipid metabolism and insulin resistance in various populations. However, whether LEPR polymorphisms are associated with the risks of non-alcoholic fatty liver disease (NAFLD) and coronary atherosclerosis in the Chinese Han population remains unknown.
Objectives: To investigate the association of LEPR polymorphisms at Q223R and K109R with the risks of NAFLD and coronary atherosclerosis in the Chinese Han population.
Patients and Methods: Genotypes of LEPRQ223R and K109R were determined by polymerase chain reaction followed by sequencing in patients with NAFLD (n=554), coronary atherosclerosis (n=421), and healthy controls (n=550). Serum lipid profiles were determined using biochemical methods. Pearson’s
c2 test was used to check for Hardy-Weinberg equilibrium and to analyze the distributions of genotypes’ alleles between groups. Baseline characteristics were analyzed using student’s t-test, paired-samples t-test, or the c2 test where appropriate.
Results: The LEPRQ223R A allele significantly reduced the risks of both NAFLD and coronary atherosclerosis (OR=0.683, 95% CI: 0.527 - 0.884, P=0.004 andOR=0.724, 95% CI: 0.548 - 0.955, P=0.022, respectively). Compared to controls, no significant differences in the genotype and allele frequencies of K109R were found in the NAFLD and coronary atherosclerosis populations, respectively. However, there was a significantly increased risk of coronary atherosclerosis in NAFLD patients who carried the K109R A allele (OR=2.283, 95% CI: 1.556 - 3.348, P<0.001).
Conclusions: LEPR Q223R polymorphisms may confer a significant risk of NAFLD and coronary atherosclerosis. The A allele in the K109R polymorphism might be considered an independent risk factor for coronary atherosclerosis in NAFLD patients.

 
Keyword(s): NON-ALCOHOLIC FATTY LIVER DISEASE, CORONARY ATHEROSCLEROSIS, SINGLE NUCLEOTIDE POLYMORPHISM, LEPR
 
 
References: 
 
Citations: 
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APA: Copy

AN, B., & LU, L., & YUAN, C., & XIN, Y., & XUAN, S. (2016). LEPTIN RECEPTOR GENE POLYMORPHISMS AND THE RISK OF NON-ALCOHOLIC FATTY LIVER DISEASE AND CORONARY ATHEROSCLEROSIS IN THE CHINESE HAN POPULATION. HEPATITIS MONTHLY, 16(4), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510534



Vancouver: Copy

AN BAI QUAN, LU LIN LIN, YUAN CHEN, XIN YONG NING, XUAN SHI YING. LEPTIN RECEPTOR GENE POLYMORPHISMS AND THE RISK OF NON-ALCOHOLIC FATTY LIVER DISEASE AND CORONARY ATHEROSCLEROSIS IN THE CHINESE HAN POPULATION. HEPATITIS MONTHLY. 2016 [cited 2021July23];16(4):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510534



IEEE: Copy

AN, B., LU, L., YUAN, C., XIN, Y., XUAN, S., 2016. LEPTIN RECEPTOR GENE POLYMORPHISMS AND THE RISK OF NON-ALCOHOLIC FATTY LIVER DISEASE AND CORONARY ATHEROSCLEROSIS IN THE CHINESE HAN POPULATION. HEPATITIS MONTHLY, [online] 16(4), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510534.



 
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