Paper Information

Journal:   JOURNAL OF CHEMICAL HEALTH RISKS (JCHR)   2016 , Volume 6 , Number 4; Page(s) 269 To 280.
 
Paper: 

THYROID FUNCTION AND SOME BIOCHEMICAL INDICES IN MALE ACTIVE SMOKERS IN CALABAR METROPOLIS

 
 
Author(s):  NSONWU ANYANWU AUGUSTA CHINYERE*, RICHARD EGBE EDMUND, JEREMAIAH OFFOR SUNDAY, SEGUN ADEOLA, ADANNA OPARA USORO CHINYERE, SUNDAY OGUNDIPE
 
* DEPARTMENT OF MEDICAL LABORATORY SCIENCE, FACULTY OF ALLIED MEDICAL SCIENCES, COLLEGE OF MEDICAL SCIENCES, UNIVERSITY OF CALABAR, NIGERIA
 
Abstract: 

Alterations in the homeostasis of biomolecules and multiple organ dysfunctions associated with cigarette smoke may suggest a dose dependent mechanism. This study assessed the triiodothyronine (T3), thyroxine (T4), thyrotropin (TSH), calcium (Ca), albumin and vitamin C levels in relation to smoking pack years (SPY) in male active smokers. Ninety consenting males (18-60 yr) comprising of moderate smokers (n=26), light smokers (n=24) and non-smokers (n=40) were studied. Triiodothyronine, thyroxine, TSH and cotinine were determined by ELISA, calcium, albumin and vitamin C by colorimetry. The BMI, calcium, albumin, vitamin C and TSH were higher and cotinine, T3 and T4 lower in non-smokers compared to moderate and light smokers.
Light smokers had higher BMI, vitamin C and TSH and lower cotinine, T3 and T4 compared to moderate smokers. In smokers, cotinine correlated positively with SPY (r=0.838, P=0.000), T3 (r=0.339, P=0.005), T4 (r=0.443, P=0.001) and negatively with BMI (r=-0.478, P=0.000), vitamin C (r=-0.407, P=0.003) and TSH (r=-0.510, P=0.000) while SPY correlated positively with T3 (r=0.586, P=0.000), T4 (r=0.608, P=0.000) and negatively with BMI (r=-0.597, P= 0.000), vitamin C (r=-0.599, P=0.000), albumin (r=-0.281, P=0.048) and TSH (r=-0.578, P =0.000). Cigarette smoking and increasing smoking pack year may be associated with abnormal thyroid function and altered calcium, albumin and vitamin C homeostasis.

 
Keyword(s): CIGARETTE, SMOKERS, THYROID FUNCTION, ALBUMIN, VITAMIN C, CALCIUM
 
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