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Paper Information

Journal:   HEPATITIS MONTHLY   2016 , Volume 16 , Number 4; Page(s) 0 To 0.
 
Paper: 

TUMOR NECROSIS FACTOR α-308 G/A POLYMORPHISMS AND RISK OF HEPATOCELLULAR CARCINOMA: A META-ANALYSIS (REVIEW ARTICLE)

 
 
Author(s):  TAVAKOLPOUR SOHEIL, SALI SHAHNAZ*
 
* INFECTIOUS DISEASES AND TROPICAL MEDICINE RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IR IRAN
 
Abstract: 

Context: Hepatocellular carcinoma (HCC) is a common disorder throughout the world that can develop due to various factors, including genetics. Tumor necrosis factor-a(TNF-a) is the most frequently studied cytokine related to the risk of developing HCC, and an association between the 308 position of the TNF-a promoter (TNFa-308) and HCCrisk has been confirmed in various reports.
Evidence Acquisition: The PubMed, Scopus, and Google Scholar databases were searched through July 12, 2015, for studies on associations between TNF-
a 308 and the risk of HCC. To determine this association, odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.
Results: A total of 23 case-control studies were investigated, involving 3, 389 cases and 4, 235 controls. The overall conclusion was that the A allele was more frequent in case groups compared to control groups (13.4% vs.8.4%). Thus, the A allele was significantly associated with increased HCC risk (OR=1.77; 95% CI=[1.26-2.50]; P value<0.002). In addition to the allelic model, the dominant model (AA+AGvs. GG) was significantly associated with HCCrisk (OR=1.80; CI= [1.29-2.51]; P value<0.001). In the sensitivity analysis for co-dominant (AA vs. GG) and recessive models (AA vs. AG+GG), no trustworthy associations with the risk of HCC development were observed.
Conclusions: This meta-analysis indicated that the TNF-
a 308 G/A polymorphism is significantly associated with increased susceptibility to HCC. However, to confirm this finding, more studies are needed on TNF-a 308 G/A polymorphisms associated with HCC.

 
Keyword(s): TUMOR NECROSIS FACTOR-α, HEPATOCELLULAR CARCINOMA, POLYMORPHISMS, TNF-α 308, META-ANALYSIS
 
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