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Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 44 To 45.
 
Paper: 

MODELING OF HEPATIC BIOCHEMICAL CHARACTERISTICS OF PATIENTS WITH UREA CYCLE DISORDERS

 
 
Author(s):  SHARIFI FATEMEH*, FIROOZABADI BAHAR, SAIDI MOHAMMAD SAID, FIROOZBAKHSH KEIKHOSROW
 
* MECHANICAL ENGINEERING FACULTY,SHARIF UNIVERSITY OF TECHNOLOGY
 
Abstract: 

Introduction: Ammonia is a very toxic substance which is removed mainly by liver through urea cycle.
If for some reason a block occurs in this cycle, some hindrances may disturb urea generation and ammonia detoxification. In this study, ammonia elimination and urea production is simulated in a hepatocytes’ microchannel mimicking the hepatic porto central axis.
Methods: Navier- Stockes equations along with convection-diffusion equations were solved for the related species in the entire domain. Urea cycle was modeled regarding its four main enzymes. Twelve rate equations were also solved in order to obtain the concentration of each metabolites participating in urea cycle. Two transporters are also considered for relating the ammonia and urea concentration of the cells to that of the channels. Different disorders related to urea cycle i.e. Hyperammonemia type I and type II, Argininosuccinicaciduria, Hyperarginemia and Citrullinemia are also studied. The distribution of the velocity in channel is obtained with the aid of the governing equation, determining the profile of the flow which brings ammonia to and carries away the generated urea from the channel. Distribution of participating metabolites is obtained along proto central axis with respect to time.
Results: Results show a mild decrease and a sharp increase in concentration of the metabolites relating to carbamoyl phosphate synthesis for hyperammonemia type I and II, respectively. Concentration of Argininosuccinate is increased nearly 15 fold in Argininosuccinicaciduria disorder. Ctrullinemia enhancesits associated metabolites circa 1.2 fold.
Conclusion: Predicted results are useful in better understanding, control and managing the effects of metabolite deficiencies on overall metabolic behavior in hepatocytes’ urea cycle.

 
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APA: Copy

SHARIFI, F., & FIROOZABADI, B., & Saidi, M., & FIROOZBAKHSH, K. (2015). MODELING OF HEPATIC BIOCHEMICAL CHARACTERISTICS OF PATIENTS WITH UREA CYCLE DISORDERS. GOVARESH JOURNAL, 20(SUPPLEMENT), 44-45. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510509



Vancouver: Copy

SHARIFI FATEMEH, FIROOZABADI BAHAR, Saidi Mohammad Said, FIROOZBAKHSH KEIKHOSROW. MODELING OF HEPATIC BIOCHEMICAL CHARACTERISTICS OF PATIENTS WITH UREA CYCLE DISORDERS. GOVARESH JOURNAL. 2015 [cited 2021July24];20(SUPPLEMENT):44-45. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510509



IEEE: Copy

SHARIFI, F., FIROOZABADI, B., Saidi, M., FIROOZBAKHSH, K., 2015. MODELING OF HEPATIC BIOCHEMICAL CHARACTERISTICS OF PATIENTS WITH UREA CYCLE DISORDERS. GOVARESH JOURNAL, [online] 20(SUPPLEMENT), pp.44-45. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510509.



 
 
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