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Paper Information

Journal:   IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)   JULY 2016 , Volume 10 , Number 4; Page(s) 197 To 204.
 
Paper: 

EFFECTS OF OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY CYTOKINES AND ADVANCED GLYCATION END PRODUCTS IN PATIENTS WITH DIABETIC NEPHROPATHY A RANDOMIZED CONTROLLED TRIAL

 
 
Author(s):  MIRHASHEMI SEYYED MEHDI, RAHIMI FAEZEH, SOLEIMANI ALIREZA, ASEMI ZATOLLAH*
 
* RESEARCH CENTER FOR BIOCHEMISTRY AND NUTRITION IN METABOLIC DISEASES, KASHAN UNIVERSITY OF MEDICAL SCIENCES, KASHAN, IRAN
 
Abstract: 

Introduction.
This study was performed to evaluate the effects of omega-3 fatty acid supplementation on inflammatory cytokines and advanced glycation end products (AGEs) in patients with diabetic nephropathy (DN).
Materials and Methods.
This randomized double-blind placebo controlled trial was done on 60 patients with DN who were randomly divided into 2 groups to receive either 1000 mg/d of omega-3 fatty acid from flaxseed oil (n=30) or placebo (n=30) for 12 weeks. The primary outcome variables were tumor necrosis factor-?, receptor tumor necrosis factor-? and growth differentiation factor 15. Fasting blood samples were taken at the onset and the end of the study to quantify the related markers.
Results.
Compared with the placebo, omega-3 fatty acid supplementation resulted in a significant decrease in serum AGEs (-2.3 ± 2.8 AU versus 0.2 ± 2.5 AU, P=.001). Despite a significant reduction in serum level of receptor for AGEs (-0.1 ± 0.3 AU, P=.02) in the omega-3 fatty acid group, no significant difference was found between the two groups in terms of their effects on the receptor for AGEs. Supplementation with omega-3 fatty acid had no significant effect on the inflammatory cytokines as compared with the placebo.
Conclusions.
Our study demonstrated that omega-3 fatty acid supplementation among DN patients had favorable effects on AGEs and the receptor for AGEs.

 
Keyword(s): OMEGA-3 FATTY ACIDS, DIABETIC NEPHROPATHY, INFLAMMATORY MARKERS, ADVANCED GLYCATION END PRODUCTS
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

MIRHASHEMI, S., & RAHIMI, F., & SOLEIMANI, A., & ASEMI, Z. (2016). EFFECTS OF OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY CYTOKINES AND ADVANCED GLYCATION END PRODUCTS IN PATIENTS WITH DIABETIC NEPHROPATHY A RANDOMIZED CONTROLLED TRIAL. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 10(4), 197-204. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510499



Vancouver: Copy

MIRHASHEMI SEYYED MEHDI, RAHIMI FAEZEH, SOLEIMANI ALIREZA, ASEMI ZATOLLAH. EFFECTS OF OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY CYTOKINES AND ADVANCED GLYCATION END PRODUCTS IN PATIENTS WITH DIABETIC NEPHROPATHY A RANDOMIZED CONTROLLED TRIAL. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD). 2016 [cited 2021July25];10(4):197-204. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510499



IEEE: Copy

MIRHASHEMI, S., RAHIMI, F., SOLEIMANI, A., ASEMI, Z., 2016. EFFECTS OF OMEGA-3 FATTY ACID SUPPLEMENTATION ON INFLAMMATORY CYTOKINES AND ADVANCED GLYCATION END PRODUCTS IN PATIENTS WITH DIABETIC NEPHROPATHY A RANDOMIZED CONTROLLED TRIAL. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), [online] 10(4), pp.197-204. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510499.



 
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