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Paper Information

Journal:   HEPATITIS MONTHLY   MARCH 2016 , Volume 16 , Number 3; Page(s) 0 To 0.
 
Paper: 

THE HBSAG PREVALENCE AMONG BLOOD DONORS FROM EASTERN MEDITERRANEAN AND MIDDLE EASTERN COUNTRIES: A SYSTEMATIC REVIEW AND META-ANALYSIS

 
 
Author(s):  BABANEJAD MEHRAN, IZADI NEDA, NAJAFI FARID, ALAVIAN SEYED MOAYED*
 
* BAQIYATALLAH RESEARCH CENTER FOR GASTROENTEROLOGY AND LIVER DISEASES, BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IR IRAN
 
Abstract: 

Context: The world health organization (WHO) recommends that all blood donations should be screened for evidence of infections, such as hepatitis B. The present study aimed to determine the prevalence of hepatitis B surface antigen (HBsAg) in blood donors at the eastern Mediterranean region office (EMRO) of the WHO and middle eastern countries.
Evidence Acquisition: A meta-analysis was carried out based on the results of an electronic literature search of PubMed, Ovid, Scopus, and Google Scholar for articles published from January 1, 2000, to August 31, 2015. In accordance with a significant homogeneity test and a large value of I2, the random effects model was used to aggregate data from the studies and produce the pooled estimates using the “Metan” command.
Results: We included 66 eligible studies. The pooled prevalence of HBsAg in blood donors of both EMRO and middle eastern (E and M) countries was 2.03% (95% confidence interval [CI]: 1.79 – 2.26). In addition, the prevalence rates in the EMRO countries was 1.99% (95% CI: 1.84 – 2.14) and 1.62% in the Middle Eastern countries (95% CI: 1.36 – 1.88). The prevalence among blood donors with more than one study was 1.58% in Egypt, 0.58% in Iran, 0.67% in Iraq, 2.84% in Pakistan, 3.02% in Saudi Arabia, 1.68% in Turkey, and 5.05% in Yemen.
Conclusions: Based on the WHO classification of hepatitis B virus (HBV) prevalence, the prevalence of HBsAg in blood donors from E andMcountries reached an intermediate level. However, there were low prevalence levels in some E andMcountries.

 
Keyword(s): PREVALENCE, HEPATITIS B, EASTERN MEDITERRANEAN, MIDDLE EAST, META-ANALYSIS
 
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