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Paper Information

Journal:   IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)   JULY 2016 , Volume 10 , Number 4; Page(s) 189 To 196.
 
Paper: 

PROTECTIVE EFFECTS OF HYDROALCOHOLIC EXTRACT OF FERULAGO ANGULATA AGAINST GENTAMICIN-INDUCED NEPHROTOXICITY IN RATS

 
 
Author(s):  VALIPOUR PARISA, HEIDARIAN ESFANDIAR*, KHOSHDEL ABOLFAZL, GHOLAMI ARJENAKI MOSTAFA
 
* CLINICAL BIOCHEMISTRY RESEARCH CENTER, SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, SHAHREKORD, IRAN
 
Abstract: 

Introduction.
Gentamicin can lead to acute tubular injury and kidney dysfunction. This study aimed to evaluate the effect of Ferulago angulataon kidney function and other markers in rats with gentamicin-induced nephrotoxicity.
Materials and Methods.
Forty-eight male Wistar rats were divided into the following groups: group 1, the controls; group 2, rats receiving gentamicin (120 mg/kg body weight per day, intraperitoneal) for 7 days without treatment; groups 3, 4 and 5, rats receiving gentamicin for 7 days and oral treatment with 200 mg/kg, 400 mg/kg, and 800 mg/kg body weight per day of Ferulago angulateextract, respectively. Measurements included serum levels of creatinine, urea, uric acid, lipids, ferric-reducing antioxidant power, and protein carbonyl; kidney and serum levels of malondialdehyde; and serum and renal levels of tumor necrosis factor-
a. Histopathology of kidney tissue was examined as well as renal catalase, superoxide dismutase, and vitamin C.
Results.
Compared to treatment with gentamicin only, treatment withFerulago angulata resulted in a significantly higher high-density lipoprotein cholesterol, ferric-reducing antioxidant plasma, renal catalase, superoxide dismutase, and vitamin C levels. It was also associated with significantly lower serum levels of creatinine, urea, uric acid, malondialdehyde, protein carbonyl, tumor necrosis factor-
a, total cholesterol, triglyceride, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol.
Ferulago angulatewas linked with a lower renal gene expression of tumor necrosis factor-
a.
Conclusions.
The present study suggests that Ferulago angulate extract has protective effects against nephrotoxicity due to gentamicin.

 
Keyword(s): FERULAGO ANGULATE, GENTAMICIN, NEPHROTOXICITY, OXIDATIVE STRESS, KIDNEY FAILURE
 
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