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Journal:   HEPATITIS MONTHLY   MARCH 2016 , Volume 16 , Number 3; Page(s) 0 To 0.
 
Paper: 

THE CORRELATION BETWEEN INTERFERON LAMBDA 3 GENE POLYMORPHISMS AND SUSCEPTIBILITY TO HEPATITIS B VIRUS INFECTION

 
 
Author(s):  HEIDARI ZAHRA, MOUDI BITA*, MAHMOUDZADEH SAGHEB HAMIDREZA, HASHEMI MOHAMMAD
 
* INFECTIOUS DISEASES AND TROPICAL MEDICINE RESEARCH CENTER, ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES, ZAHEDAN, IR IRAN
 
Abstract: 

Background: Cytokines are proteins that mediate innate and adaptive immunity responses. It is hypothesized that interferon lambda 3 (IFNL3) levels can influence the outcome of chronic hepatitis B virus (HBV) infection. Polymorphisms in IFN genes have been associated with response to infection.
Objectives: This study was carried-out to investigate the association of IFNL3 gene polymorphisms (rs12979860 and rs8099917) with HBV susceptibility, in chronic HBV-infected patients.
Patients and Methods: In this case-control study, we determined IFNL3 single nucleotide polymorphisms (SNPs) (rs12979860 and rs8099917) in 221 individuals, with chronic HBV infection, and 200 healthy individuals, who were voluntary blood donors, with negative test for HBV. Alleles and genotypes analyses were performed by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods.
Results: The frequencies of the rs12979860 and rs8099917 genotypes were not significantly different between the HBV-infected and the control groups (CC: CT: TT of 30.3%: 48.0%: 21.7% vs.33.0%: 49.0%: 18.0%, P>0.05, and GG: GT: TT of 5.8%: 39.4%: 54.8% vs.5.0%: 41.0%: 54.0%, P >0.05, respectively). Also, the frequencies of the alleles were not significantly different between both groups (C: T of 54.3%: 45.7% vs.
57.5%: 42.5%, P>0.05, and G: T of 25.6%: 74.4% vs.25.5%: 74.5%, P>0.05, respectively) and the chronic HBV infection. There were no significant differences between patients, with at least one rs12979860Candor rs8099917T allelescomparedto the healthy controls (rs12979860: CT+CC: TT, OR=1.26, 95%CI=0.78 - 2.04, P=0.341 and rs8099917: GT+TT: GG, OR=1.03, 95%CI=0.70 - 1.51, P=0.877, respectively).
Conclusions: Our study showed no correlation between rs12979860 and rs8099917 SNPs and chronic HBV infection. Further studies, with larger sample sizes and different ethnicities, are necessary to validate our findings.

 
Keyword(s): GENETIC POLYMORPHISM, CHRONIC HEPATITIS B, INTERFERON LAMBDA 3 (IFNL3)
 
 
References: 
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Citations: 
 
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APA: Copy

HEIDARI, Z., & MOUDI, B., & MAHMOUDZADEH SAGHEB, H., & HASHEMI, M. (2016). THE CORRELATION BETWEEN INTERFERON LAMBDA 3 GENE POLYMORPHISMS AND SUSCEPTIBILITY TO HEPATITIS B VIRUS INFECTION. HEPATITIS MONTHLY, 16(3), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510478



Vancouver: Copy

HEIDARI ZAHRA, MOUDI BITA, MAHMOUDZADEH SAGHEB HAMIDREZA, HASHEMI MOHAMMAD. THE CORRELATION BETWEEN INTERFERON LAMBDA 3 GENE POLYMORPHISMS AND SUSCEPTIBILITY TO HEPATITIS B VIRUS INFECTION. HEPATITIS MONTHLY. 2016 [cited 2021August02];16(3):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510478



IEEE: Copy

HEIDARI, Z., MOUDI, B., MAHMOUDZADEH SAGHEB, H., HASHEMI, M., 2016. THE CORRELATION BETWEEN INTERFERON LAMBDA 3 GENE POLYMORPHISMS AND SUSCEPTIBILITY TO HEPATITIS B VIRUS INFECTION. HEPATITIS MONTHLY, [online] 16(3), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510478.



 
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