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Paper Information

Journal:   IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)   JUNE 2016 , Volume 15 , Number 3; Page(s) 212 To 219.
 
Paper: 

EFFECTS OF INTERMITTENT FASTING ON EXPERIMENTAL AUTOIMUNE ENCEPHALOMYELITIS IN C57BL/6 MICE

 
 
Author(s):  RAZEGHI JAHROMI SOODEH, GHAEMI AMIR, ALIZADEH AKRAM, SABETGHADAM FATEMEH, MORADI TABRIZ HEDIEH, TOGHA MANSOUREH*
 
* NEUROLOGY WARD, SINA HOSPITAL, EMAM KHOMEINI STREET, TEHRAN, IRAN
 
Abstract: 

Several religions recommend periods of fasting. One of the most frequently asked questions of MS patients before the holy month of Ramadan is weather fasting might have an unfavorable effect on their disease course. This debate became more challenging after the publication of experimental studies suggesting that calorie restriction prior to disease induction attenuates disease severity. We conducted this study to assess early and late effects of fasting on the animal model of MS, known as autoimmune encephalomyelitis.
EAE was induced in the C57BL/6 mice, using Myelin Oligodendrocyte Glycopeptide (MOG) 35-55 and they fasted every other day either after the appearance of the first clinical sign or 30 days after disease induction for ten days. Thereafter, the mice were sacrificed for further histological and immunological evaluations.
Intermittent fasting after the establishment of EAE did not have any unfavorable effect on the course of disease. Moreover, fasting at the early phase of disease alleviated EAE severity by ameliorating spinal cord demyelination. Fasting suppressed the secretion of IFN-?, TNF-? and raised IL-10 production in splenocytes. Fasting was also associated with a lower percent of cytotoxicity.
Intermittent fasting not only had no unfavorable effect on EAE but also reduced EAE severity if started at early phase of disease.

 
Keyword(s): CALORIE RESTRICTION, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, FASTING, IMMUNITY, INFLAMMATION, MULTIPLE SCLEROSIS
 
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