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Paper Information

Journal:   IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)   JUNE 2016 , Volume 15 , Number 3; Page(s) 167 To 173.
 
Paper: 

ASSOCIATION OF PROMOTER POLYMORPHISMS OF INTERLEUKIN-10 AND INTERFERON-GAMMA GENES WITH TUBERCULOSIS IN AZERI POPULATION OF IRAN

 
 
Author(s):  ASGHARZADEH MOHAMMAD, GHORGHANLU SAJJAD*, RASHEDI JALIL, MAHDAVI POOR BEHROZ, KHAKI KHATIBI FATEMEH, MOADDAB SEYYED REZA, SAMADI KAFIL HOSSEIN, POUROSTADI MAHYA
 
* BIOTECHNOLOGY RESEARCH CENTER, FACULTY OF ADVANCED MEDICAL SCIENCES, UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Promoter polymorphism of cytokine genes may lead to inter-individual differences in cytokine levels, therefore, polymorphisms may associate with susceptibility to infectious diseases. In this study, we investigated a possible association between interleukin-10 (IL-10) -1082A?G (rs1800896) and interferon (IFN) -gamma+874T/A (rs2430561) promoter polymorphisms and tuberculosis (TB) in the Azeri population of Iran.
IL-10 -1082G/A and IFN-gamma+874T/A single nucleotide polymorphisms (SNPs) were genotyped by amplification refractory mutation system (ARMS) -PCR in 200 healthy controls and 124 tuberculosis patients.
IL-10 -1082 A allele was more frequent in the control group than in the patient group (p=0.001, odds ratio [OR]=2.183). On the other hand, the AA genotype was significantly more frequent in the control group (p=0.0001). The frequency of IFN-gamma+874 T allele was significantly higher in the controls (p=0.013, OR=1.56). There was no significant association between IFN-gamma+874 T/A genotypes and susceptibility to tuberculosis (p=0.078), but TT genotype was more frequent in the control group.
Our findings suggest that interleukin-10 -1082G/A polymorphism may play an important role in susceptibility to tuberculosis in our population. On the other hand, the+874T allele, which has been suggested to be associated with high IFN-gamma levels, was significantly higher in the controls and TT genotype was also more frequent in the control group. Thus, +874 T allele may be associated with resistance to tuberculosis in this Azeri population of Iran.

 
Keyword(s): ASSOCIATION, INTERFERON-GAMMA, INTERLEUKIN-10, POLYMORPHISM, SUSCEPTIBILITY, TUBERCULOSIS
 
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