Paper Information

Journal:   IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)   JUNE 2016 , Volume 15 , Number 3; Page(s) 220 To 228.
 
Paper: 

CYTOTOXIC T LYMPHOCYTE ANTIGEN-4 GENE VARIANTS IN TYPE 2 DIABETIC PATIENTS WITH OR WITHOUT NEUROPATHY

 
 
Author(s):  KIANI JAVAD, KHADEMPAR SAEDEH, HAJILOOI MEHRDAD, REZAEI HAMZEH, KESHAVARZI FATEMEH, SOLGI GHASEM*
 
* IMMUNOLOGY DEPARTMENT, SCHOOL OF MEDICINE, HAMADAN UNIVERSITY OF MEDICAL SCIENCES, MAHDIEH AVE, LONA PARK, HAMADAN, IRAN
 
Abstract: 

Many studies have shown that cytotoxic T lymphocyte antigen-4 (CTLA-4) gene variants are associated with several autoimmune diseases particularly type 1 diabetes. Due to the lack of consistent data for this association with type 2 diabetes (T2D), this study explored the possible influence of CTLA-4 gene polymorphisms at -1722 (T/C), -318 (C/T), and+49 (G/A) positions for susceptibility to T2D in relation with neuropathy.
One hundred and eleven unrelated patients with T2D [49 patients with diabetic peripheral neuropathy (DPN) and 62 patients without PDN] and 100 healthy ethnic- and gender-matched controls were included in this study. The dimorphisms at -1722 (C/T), -318 (C/T) and+49 (A/G) for CTLA-4 gene were determined using ARMS-PCR. The CTLA-4 (+49 G/G) and (+49 A/A) genotypes were found to be positively and negatively associated with T2D, respectively (p=0.03).
The -318 C/T and T/T genotypes were more frequent in patients than controls and -318 C/C genotype was shown to be protective for T2D (p=0.003). ACT and GTT Haplotypes were less and more frequent in controls and patients, respectively (p=3.86×10-7 and p=2.29×10-5). Genotypes distribution among T2D patients with and without DPN compared to healthy controls showed significantly lower frequencies for -318 C/C and+49 A/A genotypes and significantly higher frequencies for -318 C/T and T/T genotypes as well.
Our findings indicate that CTLA-4 (+49 A/G) and (-318 C/T) genotypes could be considered as genetic risk factors associated with susceptibility or protection for T2D.

 
Keyword(s): CTLA-4 ANTIGEN, DIABETES MELLITUS TYPE 2, GENES
 
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