Paper Information

Journal:   JOURNAL OF NEW MATERIALS   SUMMER 2015 , Volume 5 , Number 4 (20); Page(s) 129 To 139.
 
Paper: 

POLY (E-CAPROLACTONE)/HYDROXYAPATITE SCAFFOLD: EVALUATION OF THE EFFECT OF THE AMOUNT OF HYDROXYAPATITE PARTICLES, COMPARE OF THE EFFECT OF NANOSCALE AND MICROSCALE PARTICLES AND THE EFFECT OF THEM ON MECHANICAL AND BIODEGRADABLE PROPERTIES OF BONE TISSUE ENGINEERING SCAFFOLD

 
 
Author(s):  MOZAFFARI M., JOHARI N.*, FATHI M.H.
 
* BIOMATERIALS RESEARCH GROUP, DEPARTMENT OF MATERIALS ENGINEERING, ISFAHAN UNIVERSITY OF TECHNOLOGY, ISFAHAN, IRAN
 
Abstract: 

In this study, poly (s-caprolactone)/hydroxyapatit scaffold were produced by micro and nano hydroxyapatite. Different weight fractions of 5, 10 and 15% of the HA were added to the PCL. PCL-HA scaffolds were prepared by solvent casting/particulate leaching method. Sodium chloride (NaCl) particle was used as a porogen with diameters 250-400 mm. Structural, chemical, mechanical and biodegradation properties of scaffolds were evaluated. The pore morphology, size, and distribution of the scaffolds were characterized using a scanning electron microscope (SEM). X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) were used to determine the phase structure, chemical composition and functional groups of scaffolds. Porosity of the scaffolds was measured using Archimedes' Principle according to a known method. These scaffolds were evaluated for their compressive mechanical properties. In vitro degradation was studied by immersing of scaffolds in phosphate buffered saline (PBS) up to 30 days. The changes of pH of the PBS and the changes of the weight loss of the scaffolds were measured. Results showed compressive strength and biodegradation of scaffolds increased with the increasing the weight ratio of HA. Also, the compressive strength of the scaffolds with nano hydroxyapatite was greater than with micro hydroxyapatite. But, biodegradation of the scaffolds with nano hydroxyapatite was lesser than with micro hydroxyapatite.

 
Keyword(s): HYDROXYAPATITE, POLY (S-CAPROLACTONE), COMPOSITE SCAFFOLD, BIODEGRADATION, TISSUE ENGINEERING
 
References: 
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