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Paper Information

Journal:   GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH   2016 , Volume 9 , Number 2; Page(s) 87 To 93.
 
Paper: 

ASSOCIATION BETWEEN TWO SINGLE BASE POLYMORPHISMS OF INTERCELLULAR ADHESION MOLECULE 1 GENE AND INFLAMMATORY BOWEL DISEASE

 
 
Author(s):  HABIBI MANIJEH, NADERI NOSRATLLAH*, FARNOOD ALMA, BALAII HEDIEH, DADAEI TAHEREH, ALMASI SHOHREH, ZOJAJI HOMAYOUN, ASADZADEH AGHDAE HAMID, ZALI MOHAMMAD REZA
 
* RESEARCH INSTITUTE FOR GASTROENTEROLOGY AND LIVER DISEASES, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Aim: The present study evaluated the association between G241R and K469E polymorphisms of intercellular adhesion molecule 1 gene and inflammatory bowel disease in Iranian population.
Background: Inflammatory bowel disease including ulcerative colitis and Crohn’s disease, is a chronic idiopathic inflammatory disease of the gastrointestinal tract. There are two single base polymorphisms of intercellular adhesion molecule 1gene, G241R and K469E, reported to be associated with inflammatory disorders.
Patients and methods: In this case-control study, 156 inflammatory bowel disease patients (110 ulcerative colitis and 46 Crohn’s disease patients) and 131 healthy controls were enrolled. Two polymorphisms of intercellular adhesion molecule 1 gene, including G241R and K469E, were assessed by polymerase chain reaction followed by restriction fragment length polymorphism.
Results: The E469 allele of K469E polymorphism was significantly more frequent in Crohn’s disease patients compared to controls (P< 0.05, OR= 1.83; 95% CI: 1.13 to 2.96). The mutant homozygote genotype of K469E polymorphism (E/E) was also significantly more frequent in Crohn’s disease patients compared to controls (P< 0.05, OR= 4.23; 95% CI: 1.42 to 12.59). No difference was observed in the frequency of K469E polymorphism among ulcerative colitis patients compared to controls. There were no significant differences in genotype and allele frequencies of G241R polymorphism among ulcerative colitis and Crohn’s disease patients compared to control subjects.
Conclusion: According to our findings, K469E polymorphism of intercellular adhesion molecule 1 gene may probably participate in the pathogenesis of Crohn’s disease in Iran.

 
Keyword(s): INFLAMMATORY BOWEL DISEASE, ICAM1 GENE, POLYMORPHISM, CROHN’S DISEASE
 
 
References: 
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APA: Copy

HABIBI, M., & NADERI, N., & FARNOOD, A., & BALAII, H., & DADAEI, T., & ALMASI, S., & ZOJAJI, H., & ASADZADEH AGHDAE, H., & ZALI, M. (2016). ASSOCIATION BETWEEN TWO SINGLE BASE POLYMORPHISMS OF INTERCELLULAR ADHESION MOLECULE 1 GENE AND INFLAMMATORY BOWEL DISEASE. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 9(2), 87-93. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510368



Vancouver: Copy

HABIBI MANIJEH, NADERI NOSRATLLAH, FARNOOD ALMA, BALAII HEDIEH, DADAEI TAHEREH, ALMASI SHOHREH, ZOJAJI HOMAYOUN, ASADZADEH AGHDAE HAMID, ZALI MOHAMMAD REZA. ASSOCIATION BETWEEN TWO SINGLE BASE POLYMORPHISMS OF INTERCELLULAR ADHESION MOLECULE 1 GENE AND INFLAMMATORY BOWEL DISEASE. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH. 2016 [cited 2021July29];9(2):87-93. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510368



IEEE: Copy

HABIBI, M., NADERI, N., FARNOOD, A., BALAII, H., DADAEI, T., ALMASI, S., ZOJAJI, H., ASADZADEH AGHDAE, H., ZALI, M., 2016. ASSOCIATION BETWEEN TWO SINGLE BASE POLYMORPHISMS OF INTERCELLULAR ADHESION MOLECULE 1 GENE AND INFLAMMATORY BOWEL DISEASE. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, [online] 9(2), pp.87-93. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510368.



 
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