Paper Information

Journal:   GOVARESH JOURNAL   FALL 2015 , Volume 20 , Number SUPPLEMENT; Page(s) 41 To 42.
 
Paper: 

FATTY LIVER INDEX VALUE FOR NON-ALCOHOLIC FATTY LIVER DISEASE: A POPULATION BASED STUDY

 
 
Author(s):  ZAMANI FARHAD, KHOONSARI MAHMOOD, SOHRABI MASOUDREZA, MAADI MASOUMEH, MOTAMED NIMA*
 
* DEPARTMENT OF SOCIAL MEDICINE, ZANJAN UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Introduction: This study was conducted to determine the discriminatory performance of Fatty liver index (FLI) for nonalcoholic fatty liver disease (NAFLD).
Methods: The data of 5052 subjects aged over 18 years were analyzed. FLI was calculated based on data of body mass index (BMI), waist circumference (WC), triglyceride (TG) and gamma glutamyl transferase (GGT).
Logistic regression analysis was conducted to determine the association between FLI and NAFLD.
The discriminatory performance of FLI in the diagnosis of NAFLD was evaluated by receiver operating characteristic (ROC) analysis. Area under the curves (AUCs) and related confidence intervals were estimated. Optimal cutoff points of FLI in the diagnosis of NAFLD were determined based on the maximum values of youden index.
Results: The mean age of men and women were 44.8
?} 16.8 and 43.78± 15.43, respectively (p-value =0.0216). The prevalence of NAFLD was 40.1 % in men and 44.2% in women (p-value<0.0017). FLI was strongly associated with NAFLD, so that one unit increase in FLI increased the chance of developing NAFLD 5.8% (OR=1.058, [95%CI= (1.054-1.063)], p-value<0.0001).
Although FLI revealed a good performance in the diagnosis of NAFLD (AUC=0.8656 (95% CI=0.8548-0.8764), its performance had not significant difference with WC (AUC=0.8533, 0.95% CI=0.8419-0.8646).
According sex the performance of FLI was not different between men (AUC=0.8648 [0.95% CI=0.8505- 0.8791]) and women (AUC=0.8682- [0.95% CI=0.8513- 0.8851]) while based on age the highest performance was related to the age group of 18-39 (AUC=0.8930 [0.95% CI=0.8766- 0.9093]).
The optimal cutoff points of FLI were 46.9 in men (sensitivity=0.8242, specificity=0.7687, Youden index=0.5929) and 53.8 in women (sensitivity= 0.8233, specificity=0.7655, Youden index=0.5888).
Conclusion: FLI had an acceptable discriminatorypower in the diagnosis of NAFLD, however WC as a more simple and accessible index revealed similar performance.

 
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