Paper Information

Journal:   IRANIAN JOURNAL OF NEUROLOGY   2016 , Volume 15 , Number 2; Page(s) 80 To 84.
 
Paper: 

ASSOCIATION BETWEEN ALA379VAL ‎POLYMORPHISM OF LIPOPROTEIN-‎ASSOCIATED PHOSPHOLIPASE ‎A2 AND MIGRAINE WITHOUT ‎AURA IN IRANIAN POPULATION

 
 
Author(s):  HAGHDOOST FARAIDOON, GHARZI MAHSA, FAEZ FAROUGH, HOSSEINZADEH ELINAZ, TAJADDINI MOHAMADHASAN, RAFIEI LALEH, ASGARI FATEMEH, BANIHASHEMI MAHBOOBEH, MASJEDI SAMANEH SADAT, ZANDIFAR ALIREZA, HAGHJOOY JAVANMARD SHAGHAYEGH
 
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Abstract: 

Background: Migraine is a common neurovascular disorder with multifactorial and polygenic inheritance. The aim of this study was to investigate the association of a migraine without aura and Ala379Val polymorphism of lipoprotein-associated phospholipase A2 (Lp-PLA2) gene in the Iranian population.
Methods: In this study, 103 migraine patients and 100 healthy controls were enrolled. DNA samples were extracted and the Ala379Val polymorphism of Lp-PLA2 gene was investigated. To assess severity of a headache, patients filled out the headache impact test (HIT-6) and migraine severity (MIGSEV) questionnaires.
Results: Allele V had significantly lower frequency in the case group than control subjects [P=0.001, odds ratio (OR) = 0.25, confidence interval (CI): 0.15-0.40]. The frequency of migraine patients that were a carrier of V allele (V/V and A/V) was statistically significant lower than the control group (P=0.003, OR = 2.39, CI: 1.35-4.23). There was no significant difference of alleles frequency between three grades of MIGSEV (P=0.316). Furthermore, total HIT-6 score was not significantly different between different genotypes (P=0.466).
Conclusion: Our results showed that Ala379Val gene polymorphism of LP-PLA2 is associated with lower risk of migraine but not with severity of headaches in an Iranian population.

 
Keyword(s): HEADACHE, LP-PLA2, MIGRAINE, GENE POLYMORPHISM, ‎QUESTIONNAIRES
 
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