Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES   SPRING 2016 , Volume 23 , Number 1; Page(s) 0 To 0.
 
Paper: 

THE EFFECT OF DIFFERENT DOSES OF VITAMIN D SUPPLEMENTATION ON INSULIN RESISTANCE IN OVARIECTOMIZED RATS

 
 
Author(s):  HOSEINI RASTEGAR*, BABAEI PARVIN, DAMIRCHI ARSALAN
 
* DEPARTMENT OF EXERCISE PHYSIOLOGY, FACULTY OF PHYSICAL EDUCATION AND SPORT SCIENCES, RAZI UNIVERSITY OF KERMANSHAH, KERMANSHAH, IRAN
 
Abstract: 

Background and Aim: Type 2 diabetes mellitus (T2DM) and vitamin D deficiency are both too common during menopause. Since the effect of different doses of vitamin D supplements on blood sugar, insulin concentration and insulin resistance are unknown, the present study aimed at investigating the effects of different doses of the vitamin D supplements on visceral fat, blood sugar, insulin concentration, and insulin resistance in ovariectomized rats.
Materials and Methods: In this randomized experimental study, 32 female Wistar rats were divided into 4 equal groups as follows: three groups. that received vitamin D supplements (high, moderate, and low dose) and one control group. After 8 weeks of different doses of vitamin D supplementation plasma concentration of glucose, insulin and HOMA-IR were measured in the three groups. The obtained data was statistically analyzed by means of dependent t-test and ANOVA. at the significance level of P<0.05.
Results: After a period of eight-week intervention, body weight, BMI, waist circumference, visceral fat, insulin, blood glucose and HOMA-IR at high, moderate, and low doses of vitamin D supplementation were significantly lower than those in the control group (P<0.05). High dose of vitamin D compared with moderate and low doses significantly caused reduction in insulin, blood glucose, and HOMA-IR (P<0.001 for all three variables).
Conclusion: The findings of the current study showed that a high dose of vitamin D causes significant improvements in FPG, insulin, and insulin resistance evaluated by HOMA-IR. It was also found that adding vitamin D supplements can improve glucose control in menopause model of rats.

 
Keyword(s): VITAMIN D SUPPLEMENTATION, OVARIECTOMIZED, INSULIN RESISTANT
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

HOSEINI, R., & BABAEI, P., & DAMIRCHI, A. (2016). THE EFFECT OF DIFFERENT DOSES OF VITAMIN D SUPPLEMENTATION ON INSULIN RESISTANCE IN OVARIECTOMIZED RATS. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 23(1), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510304



Vancouver: Copy

HOSEINI RASTEGAR, BABAEI PARVIN, DAMIRCHI ARSALAN. THE EFFECT OF DIFFERENT DOSES OF VITAMIN D SUPPLEMENTATION ON INSULIN RESISTANCE IN OVARIECTOMIZED RATS. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES. 2016 [cited 2021August03];23(1):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510304



IEEE: Copy

HOSEINI, R., BABAEI, P., DAMIRCHI, A., 2016. THE EFFECT OF DIFFERENT DOSES OF VITAMIN D SUPPLEMENTATION ON INSULIN RESISTANCE IN OVARIECTOMIZED RATS. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, [online] 23(1), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510304.



 
 
Yearly Visit 30
 
 
Latest on Blog
Enter SID Blog