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Paper Information

Journal:   HEPATITIS MONTHLY   FEBRUARY 2016 , Volume 16 , Number 2 ; Page(s) 0 To 0.
 
Paper: 

IMMUNE RESPONSES TO SINGLE-DOSE VERSUS DOUBLE-DOSE HEPATITIS B VACCINES IN HEALTHCARE WORKERS NOT RESPONDING TO THE PRIMARY VACCINE SERIES: A RANDOMIZED CLINICAL TRIAL

 
 
Author(s):  JOUKAR FARAHNAZ, MANSOUR GHANAEI FARIBORZ*, NAGHIPOUR MOHAMMAD REZA, ASGHARNEZHAD MEHRNAZ
 
* GASTROINTESTINAL AND LIVER DISEASES RESEARCH CENTER (GLDRC), GUILAN UNIVERSITY OF MEDICAL SCIENCES, RASHT, IR IRAN
 
Abstract: 

Background: Recommendations to immunize healthcare workers (HCWs) against hepatitis B are well known. However, a proportion of individuals do not respond to the primary standard three-dose HB vaccination schedule.
Objectives: The current study aimed to evaluate whether a double-dose HB booster vaccine could induce better protective anti-HB titers than a single-dose booster in non-protected HCWs.
Materials and Methods: This was a randomized clinical trial. A total of 91 HCWs not responding to the primary vaccine series in 2014 were enrolled. The participants were randomized into two groups that received a double dose of the HB vaccine containing 40 ?g of antigen or a single dose of the HB vaccine containing 20 ?g of antigen in three doses (at zero, one and six months after vaccination). Blood samples were collected before vaccinations and 28 days after the third dose to assess the seroconversion rate, according to the anti-HB antibody titer threshold of>10 mIU/mL.
Results: The seroconversion rates were 93.2% and 87.2% after the first booster doses of the double-dose and single-dose HB vaccines, respectively (P=0.64). In the double-dose HB vaccine group, the seroconversion rate was 97.8% compared with 89.6% in the single-dose group following the second vaccine dose (P=0.83). All of the participants in both groups were seroprotected after the third HB vaccine dose.
Conclusions: Both the single- and double-dose HB vaccines were adequately immunogenic, and the double-dose HB vaccine was not significantly more immunogenic than the single-dose vaccine in terms of the seroconversion rates of HCWs who had not responded to the primary vaccine series.

 
Keyword(s): HEALTHCARE PERSONNEL, IMMUNOGENICITY, IMMUNE RESPONSE ANTIGENS, HEPATITIS B VACCINE, HEALTHCARE
 
 
References: 
 
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APA: Copy

JOUKAR, F., & MANSOUR GHANAEI, F., & NAGHIPOUR, M., & ASGHARNEZHAD, M. (2016). IMMUNE RESPONSES TO SINGLE-DOSE VERSUS DOUBLE-DOSE HEPATITIS B VACCINES IN HEALTHCARE WORKERS NOT RESPONDING TO THE PRIMARY VACCINE SERIES: A RANDOMIZED CLINICAL TRIAL. HEPATITIS MONTHLY, 16(2), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510266



Vancouver: Copy

JOUKAR FARAHNAZ, MANSOUR GHANAEI FARIBORZ, NAGHIPOUR MOHAMMAD REZA, ASGHARNEZHAD MEHRNAZ. IMMUNE RESPONSES TO SINGLE-DOSE VERSUS DOUBLE-DOSE HEPATITIS B VACCINES IN HEALTHCARE WORKERS NOT RESPONDING TO THE PRIMARY VACCINE SERIES: A RANDOMIZED CLINICAL TRIAL. HEPATITIS MONTHLY. 2016 [cited 2021July26];16(2):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510266



IEEE: Copy

JOUKAR, F., MANSOUR GHANAEI, F., NAGHIPOUR, M., ASGHARNEZHAD, M., 2016. IMMUNE RESPONSES TO SINGLE-DOSE VERSUS DOUBLE-DOSE HEPATITIS B VACCINES IN HEALTHCARE WORKERS NOT RESPONDING TO THE PRIMARY VACCINE SERIES: A RANDOMIZED CLINICAL TRIAL. HEPATITIS MONTHLY, [online] 16(2), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510266.



 
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