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Paper Information

Journal:   HEPATITIS MONTHLY   FEBRUARY 2016 , Volume 16 , Number 2 ; Page(s) 0 To 0.
 
Paper: 

THE ITPA AND C20ORF194 POLYMORPHISMS AND HEMATOLOGICAL CHANGES DURING TREATMENT WITH PEGYLATED-INTERFERON PLUS RIBAVIRIN IN PATIENTS WITH CHRONIC HEPATITIS C

 
 
Author(s):  POURYASIN MOHAMMAD, KESHVARI MARYAM, SHARAFI HEIDAR, ALAVIAN SEYED MOAYED, BEHNAVA BITA, ALAVIAN SEYED EHSAN, POURYASIN ALI*
 
* ARMIN PATHOBIOLOGY LABORATORY, TEHRAN, IR IRAN
 
Abstract: 

Background: It has been found that ITPase deficiency is caused by ITPA gene polymorphisms. It was observed that ITPA polymorphisms have impact on hematological changes, including hemoglobin (Hb) -decline during treatment of chronic hepatitis C (CHC) patients with pegylated-interferon (PEG-IFN) plus ribavirin (RBV).
Objectives: This study aimed to assess the effect of ITPA and C20orf194 polymorphisms on hematological changes at week 4 of treatment with PEG-IFN plus RBV in patients with CHC.
Patients and Methods: In this retrospective study, 168 patients with CHC (56% HCV genotype-1 and 44% HCV genotype-3) under the treatment of PEG-IFN plus RBV were genotyped for rs1127354, rs7270101 and rs6051702 polymorphisms by the polymerase chain reaction-restriction fragment length polymorphism. Hematological changes including Hb-, platelet (Plt) - and white blood cell-decline at week 4 of the treatment were assessed.
Results: In univariate analysis, rs1127354 and HCV genotypes were found to influence the Hb-decline at week 4 of the treatment. In multivariate analysis, rs1127354 CA+AA and HCV genotype-3 were found to have a great role on prevention of Hb-decline. Furthermore, rs1127354 and HCV RNA levels were found to influence the Plt-decline at week 4 of the treatment in the univariate analysis. In multivariate analysis, rs1127354 CA+AA and HCV RNA levels less than 600, 000 IU/mL were found to be associated with a higher level of Plt-decline.
Conclusions: In patients with CHC, who were treated with PEG-IFN plus RBV, Hb-decline was affected by rs1127354 and HCV genotypes. However, Plt-decline may be altered by rs1127354 and baseline HCV RNA levels.

 
Keyword(s): GENETIC POLYMORPHISM, CHRONIC HEPATITIS C, HUMAN ITPA PROTEIN
 
 
References: 
 
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APA: Copy

POURYASIN, M., & KESHVARI, M., & SHARAFI, H., & ALAVIAN, S., & BEHNAVA, B., & POURYASIN, A. (2016). THE ITPA AND C20ORF194 POLYMORPHISMS AND HEMATOLOGICAL CHANGES DURING TREATMENT WITH PEGYLATED-INTERFERON PLUS RIBAVIRIN IN PATIENTS WITH CHRONIC HEPATITIS C. HEPATITIS MONTHLY, 16(2), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510246



Vancouver: Copy

POURYASIN MOHAMMAD, KESHVARI MARYAM, SHARAFI HEIDAR, ALAVIAN SEYED MOAYED, BEHNAVA BITA, POURYASIN ALI. THE ITPA AND C20ORF194 POLYMORPHISMS AND HEMATOLOGICAL CHANGES DURING TREATMENT WITH PEGYLATED-INTERFERON PLUS RIBAVIRIN IN PATIENTS WITH CHRONIC HEPATITIS C. HEPATITIS MONTHLY. 2016 [cited 2021July26];16(2):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510246



IEEE: Copy

POURYASIN, M., KESHVARI, M., SHARAFI, H., ALAVIAN, S., BEHNAVA, B., POURYASIN, A., 2016. THE ITPA AND C20ORF194 POLYMORPHISMS AND HEMATOLOGICAL CHANGES DURING TREATMENT WITH PEGYLATED-INTERFERON PLUS RIBAVIRIN IN PATIENTS WITH CHRONIC HEPATITIS C. HEPATITIS MONTHLY, [online] 16(2), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510246.



 
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