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Paper Information

Journal:   HEPATITIS MONTHLY   FEBRUARY 2016 , Volume 16 , Number 2 ; Page(s) 0 To 0.
 
Paper: 

ASSOCIATION BETWEEN IL-10 GENE PROMOTER POLYMORPHISMS (-592 A/C, -819 T/C, -1082 A/G) AND SUSCEPTIBILITY TO HBV INFECTION IN AN IRANIAN POPULATION

 
 
Author(s):  MOUDI BITA, HEIDARI ZAHRA*, MAHMOUDZADEH SAGHEB HAMIDREZA, HASHEMI MOHAMMAD, METANAT MALIHEH, KHOSRAVI SOHEILA, FARROKH PARISA
 
* DEPARTMENT OF HISTOLOGY, SCHOOL OF MEDICINE, ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES, ZAHEDAN, IR IRAN
 
Abstract: 

Background: IL-10 can play a vital role in immune response against HBV. Three biallelic SNPs from the transcription start site control the transcription of the IL-10 gene. An association between susceptibility to HBV and IL-10 polymorphisms has been suggested in patients with HBV infection.
Objectives: The present study was designed to study the association between polymorphisms in interleukin-10 (-1082 A/G, -819 T/C and -592 A/C) promoter gene and chronic hepatitis B virus (HBV) infection.
Patients and Methods: 221 chronically infected patients and 200 healthy control subjects were enrolled in the study. Three biallelic (-1082 A/G, -819 T/C and -592 A/C) polymorphisms in the IL-10 promoter gene were determined by PCR-RFLP method.
Results: Persistent HBV infection was associated with IL-10-1082 AG (P=0.001) and GG (P=0.004) genotypes and G (P=0.000) allele. IL-10-819 T/C and -592 A/C genotype and allele frequencies did not show any correlation with the risk of chronic hepatitis B infection.
Conclusions: These results suggest that polymorphisms in interleukin-10 gene promoter influence clinical outcome of HBV infection and susceptibility to HBV infection.

 
Keyword(s): CHRONIC HEPATITIS B, INTERLEUKIN-10, SINGLE NUCLEOTIDE POLYMORPHISM
 
 
References: 
 
Citations: 
 
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APA: Copy

MOUDI, B., & HEIDARI, Z., & MAHMOUDZADEH SAGHEB, H., & HASHEMI, M., & METANAT, M., & KHOSRAVI, S., & FARROKH, P. (2016). ASSOCIATION BETWEEN IL-10 GENE PROMOTER POLYMORPHISMS (-592 A/C, -819 T/C, -1082 A/G) AND SUSCEPTIBILITY TO HBV INFECTION IN AN IRANIAN POPULATION. HEPATITIS MONTHLY, 16(2), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510222



Vancouver: Copy

MOUDI BITA, HEIDARI ZAHRA, MAHMOUDZADEH SAGHEB HAMIDREZA, HASHEMI MOHAMMAD, METANAT MALIHEH, KHOSRAVI SOHEILA, FARROKH PARISA. ASSOCIATION BETWEEN IL-10 GENE PROMOTER POLYMORPHISMS (-592 A/C, -819 T/C, -1082 A/G) AND SUSCEPTIBILITY TO HBV INFECTION IN AN IRANIAN POPULATION. HEPATITIS MONTHLY. 2016 [cited 2021August02];16(2):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510222



IEEE: Copy

MOUDI, B., HEIDARI, Z., MAHMOUDZADEH SAGHEB, H., HASHEMI, M., METANAT, M., KHOSRAVI, S., FARROKH, P., 2016. ASSOCIATION BETWEEN IL-10 GENE PROMOTER POLYMORPHISMS (-592 A/C, -819 T/C, -1082 A/G) AND SUSCEPTIBILITY TO HBV INFECTION IN AN IRANIAN POPULATION. HEPATITIS MONTHLY, [online] 16(2), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510222.



 
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