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Paper Information

Journal:   ACTA MEDICA IRANICA   2016 , Volume 54 , Number 7; Page(s) 410 To 417.
 
Paper: 

EFFECTS OF DHA SUPPLEMENTATION ON VASCULAR FUNCTION, TELOMERASE ACTIVITY IN PBMC, EXPRESSION OF INFLAMMATORY CYTOKINES, AND PPAR?-LXRα-ABCA1 PATHWAY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: STUDY PROTOCOL FOR RANDOMIZED CONTROLLED CLINICAL TRIAL

 
 
Author(s):  TOUPCHIAN OMID, SOTOUDEH GITY*, MANSOORI ANAHITA, DJALALI MAHMOUD, KESHAVARZ SEYYED ALI, NASLI ESFAHANI ENSIEH, ALVANDI EHSAN, KOOHDANI FARIBA*
 
* DEPARTMENT OF CELLULAR AND MOLECULAR NUTRITION, SCHOOL OF NUTRITIONAL SCIENCES AND DIETETICS, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Docosahexaenoic acid (DHA), as an omega-3 fatty acid, in a natural ligand of peroxisome proliferator-activated receptors (PPARs). Regarding the combinative effects of Nutrigenomics and Nutrigenetics and due to the lack of in vivo studies conducted using natural ligands of PPARs, we aimed to evaluate the effects of DHA supplementation on vascular function, telomerase activity, and PPAR?-LXRa-ABCA1 pathway, in patients with type 2 diabetes mellitus (T2DM), based on the Pro12Ala polymorphism in PPAR? encoding gene.72 T2DM patients (36 dominant and 36 recessive allele carriers), aged 30-70, with body mass index of 18.5 to 35 kg/m2, will be participated in this double blind randomized controlled trial. In each group, stratification will be performed based on sex and age and participants will be randomly assigned to receive 2.4 g/day DHA or placebo (paraffin) for 8 weeks. PPAR? genotyping will be carried out using PCR-RFLP method, Telomerase activity will be estimated by PCR-ELISA TRAP assay, mRNA expression levels of target genes will be assessed using real time PCR. Serum levels of ADMA, sCD163 and adiponectin, will be measured using ELISA commercial kits. The present study is designed in order to help T2DM patients to modify their health conditions based on their genetic backgrounds, and to recommend the proper food ingredients as the natural agonists for PPARs in order to prevent and treat metabolic abnormalities of the disease.

 
Keyword(s): TYPE 2 DIABETES MELLITUS, TELOMERASE ACTIVITY, DOCOSAHEXAENOIC ACID, ADMA, SCD163
 
 
References: 
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APA: Copy

TOUPCHIAN, O., & SOTOUDEH, G., & MANSOORI, A., & DJALALI, M., & KESHAVARZ, S., & NASLI ESFAHANI, E., & ALVANDI, E., & KOOHDANI, F. (2016). EFFECTS OF DHA SUPPLEMENTATION ON VASCULAR FUNCTION, TELOMERASE ACTIVITY IN PBMC, EXPRESSION OF INFLAMMATORY CYTOKINES, AND PPAR?-LXRα-ABCA1 PATHWAY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: STUDY PROTOCOL FOR RANDOMIZED CONTROLLED CLINICAL TRIAL. ACTA MEDICA IRANICA, 54(7), 410-417. https://www.sid.ir/en/journal/ViewPaper.aspx?id=510190



Vancouver: Copy

TOUPCHIAN OMID, SOTOUDEH GITY, MANSOORI ANAHITA, DJALALI MAHMOUD, KESHAVARZ SEYYED ALI, NASLI ESFAHANI ENSIEH, ALVANDI EHSAN, KOOHDANI FARIBA. EFFECTS OF DHA SUPPLEMENTATION ON VASCULAR FUNCTION, TELOMERASE ACTIVITY IN PBMC, EXPRESSION OF INFLAMMATORY CYTOKINES, AND PPAR?-LXRα-ABCA1 PATHWAY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: STUDY PROTOCOL FOR RANDOMIZED CONTROLLED CLINICAL TRIAL. ACTA MEDICA IRANICA. 2016 [cited 2021July25];54(7):410-417. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510190



IEEE: Copy

TOUPCHIAN, O., SOTOUDEH, G., MANSOORI, A., DJALALI, M., KESHAVARZ, S., NASLI ESFAHANI, E., ALVANDI, E., KOOHDANI, F., 2016. EFFECTS OF DHA SUPPLEMENTATION ON VASCULAR FUNCTION, TELOMERASE ACTIVITY IN PBMC, EXPRESSION OF INFLAMMATORY CYTOKINES, AND PPAR?-LXRα-ABCA1 PATHWAY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: STUDY PROTOCOL FOR RANDOMIZED CONTROLLED CLINICAL TRIAL. ACTA MEDICA IRANICA, [online] 54(7), pp.410-417. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=510190.



 
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